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    Anks3 ankyrin repeat and sterile alpha motif domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 72615, updated on 9-Dec-2024

    Summary

    Official Symbol
    Anks3provided by MGI
    Official Full Name
    ankyrin repeat and sterile alpha motif domain containing 3provided by MGI
    Primary source
    MGI:MGI:1919865
    See related
    Ensembl:ENSMUSG00000022515 AllianceGenome:MGI:1919865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1977; 2700067D09Rik
    Summary
    Located in cilium and cytoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 12.6), CNS E18 (RPKM 12.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Anks3 in Genome Data Viewer
    Location:
    16 A1; 16 2.48 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4759290..4783362, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4941415..4965537, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mahogunin, ring finger 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:4938936-4939237 Neighboring gene predicted gene, 16861 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene predicted gene, 36681 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ankyrin repeat and SAM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028301.5NP_082577.2  ankyrin repeat and SAM domain-containing protein 3

      See identical proteins and their annotated locations for NP_082577.2

      Status: VALIDATED

      Source sequence(s)
      AC163723, AC240849
      Consensus CDS
      CCDS27928.1
      UniProtKB/Swiss-Prot
      Q6ZPF6, Q80X46, Q9CZK6
      Related
      ENSMUSP00000023157.5, ENSMUST00000023157.6
      Conserved Domains (6) summary
      cd09519
      Location:423486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      smart00454
      Location:422481
      SAM; Sterile alpha motif
      cd00204
      Location:63189
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:106199
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:512608
      DUF4570; Domain of unknown function (DUF4570)
      sd00045
      Location:6999
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4759290..4783362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522608.2XP_006522671.1  ankyrin repeat and SAM domain-containing protein 3 isoform X1

      Conserved Domains (5) summary
      cd09519
      Location:423486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:29192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:6999
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:169221
      Ank_4; Ankyrin repeats (many copies)
      pfam15134
      Location:512608
      DUF4570; Domain of unknown function (DUF4570)
    2. XM_006522610.3XP_006522673.1  ankyrin repeat and SAM domain-containing protein 3 isoform X3

      Conserved Domains (5) summary
      cd09519
      Location:423486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:29192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:6999
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:169221
      Ank_4; Ankyrin repeats (many copies)
      pfam15134
      Location:512608
      DUF4570; Domain of unknown function (DUF4570)
    3. XM_036160143.1XP_036016036.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

      Conserved Domains (3) summary
      cd09519
      Location:350413
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:2859
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:33126
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_030249288.2XP_030105148.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

      Conserved Domains (5) summary
      cd09519
      Location:362425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451547
      DUF4570; Domain of unknown function (DUF4570)
    5. XM_036160146.1XP_036016039.1  ankyrin repeat and SAM domain-containing protein 3 isoform X14

      Conserved Domains (2) summary
      cd09519
      Location:250313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      cl39094
      Location:148
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_006522609.4XP_006522672.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

      Conserved Domains (5) summary
      cd09519
      Location:423486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:29192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:6999
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:169221
      Ank_4; Ankyrin repeats (many copies)
      pfam15134
      Location:512608
      DUF4570; Domain of unknown function (DUF4570)
    7. XM_030249290.2XP_030105150.1  ankyrin repeat and SAM domain-containing protein 3 isoform X9

      Conserved Domains (5) summary
      cd09519
      Location:362425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451547
      DUF4570; Domain of unknown function (DUF4570)
    8. XM_030249287.1XP_030105147.1  ankyrin repeat and SAM domain-containing protein 3 isoform X6

      Conserved Domains (5) summary
      cd09519
      Location:362425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451547
      DUF4570; Domain of unknown function (DUF4570)
    9. XM_006522611.5XP_006522674.1  ankyrin repeat and SAM domain-containing protein 3 isoform X4

      Conserved Domains (5) summary
      cd09519
      Location:362425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451547
      DUF4570; Domain of unknown function (DUF4570)
    10. XM_030249289.2XP_030105149.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

      Conserved Domains (3) summary
      cd09519
      Location:350413
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:2859
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:33126
      Ank_2; Ankyrin repeats (3 copies)
    11. XM_006522612.3XP_006522675.1  ankyrin repeat and SAM domain-containing protein 3 isoform X5

      Conserved Domains (4) summary
      cd09519
      Location:350413
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:2859
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:33126
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:439535
      DUF4570; Domain of unknown function (DUF4570)
    12. XM_036160145.1XP_036016038.1  ankyrin repeat and SAM domain-containing protein 3 isoform X12

      Conserved Domains (3) summary
      cd09519
      Location:294357
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:536
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:170
      Ank_2; Ankyrin repeats (3 copies)
    13. XM_006522613.4XP_006522676.1  ankyrin repeat and SAM domain-containing protein 3 isoform X10

      Conserved Domains (4) summary
      cd09519
      Location:294357
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:536
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:170
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:383479
      DUF4570; Domain of unknown function (DUF4570)
    14. XM_030249291.2XP_030105151.1  ankyrin repeat and SAM domain-containing protein 3 isoform X11

      Conserved Domains (3) summary
      cd09519
      Location:250313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      pfam12796
      Location:148
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:339435
      DUF4570; Domain of unknown function (DUF4570)
    15. XM_030249294.2XP_030105154.1  ankyrin repeat and SAM domain-containing protein 3 isoform X13

      Conserved Domains (3) summary
      cd09519
      Location:250313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      pfam12796
      Location:148
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:339435
      DUF4570; Domain of unknown function (DUF4570)
    16. XM_030249292.2XP_030105152.1  ankyrin repeat and SAM domain-containing protein 3 isoform X11

      Conserved Domains (3) summary
      cd09519
      Location:250313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      pfam12796
      Location:148
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:339435
      DUF4570; Domain of unknown function (DUF4570)

    RNA

    1. XR_004939242.1 RNA Sequence

    2. XR_004939236.1 RNA Sequence

    3. XR_004939235.1 RNA Sequence

    4. XR_004939234.1 RNA Sequence

    5. XR_004939239.1 RNA Sequence

    6. XR_004939238.1 RNA Sequence

    7. XR_003951838.1 RNA Sequence

    8. XR_004939237.1 RNA Sequence

    9. XR_004939241.1 RNA Sequence

    10. XR_004939240.1 RNA Sequence

    11. XR_003951841.1 RNA Sequence

    12. XR_003951840.1 RNA Sequence