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    Cry2 cryptochrome circadian regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 12953, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cry2provided by MGI
    Official Full Name
    cryptochrome circadian regulator 2provided by MGI
    Primary source
    MGI:MGI:1270859
    See related
    Ensembl:ENSMUSG00000068742 AllianceGenome:MGI:1270859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130054K12Rik
    Summary
    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in cortex adult (RPKM 22.9), frontal lobe adult (RPKM 22.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cry2 in Genome Data Viewer
    Location:
    2; 2 E1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92233991..92264426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92403646..92434085, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene Frey regulator of sperm-oocyte fusion 1 Neighboring gene microRNA 7000 Neighboring gene RIKEN cDNA D930015M05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1248 Neighboring gene STARR-positive B cell enhancer ABC_E4481 Neighboring gene solute carrier family 35, member C1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:92324700-92325001 Neighboring gene predicted gene 13817

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables photoreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian regulation of gene expression NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in lipid storage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of circadian rhythm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of glucocorticoid receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of glucocorticoid secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein import into nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sodium-dependent phosphate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to insulin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cry-Per complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cryptochrome-2
    Names
    cryptochrome 2 (photolyase-like)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009963.4NP_034093.1  cryptochrome-2

      See identical proteins and their annotated locations for NP_034093.1

      Status: VALIDATED

      Source sequence(s)
      AK172994, BC054794, CJ164467
      Consensus CDS
      CCDS16447.1
      UniProtKB/Swiss-Prot
      O08706, Q6A024, Q9R194
      Related
      ENSMUSP00000088047.6, ENSMUST00000090559.12
      Conserved Domains (2) summary
      COG0415
      Location:21509
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:306504
      FAD_binding_7; FAD binding domain of DNA photolyase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      92233991..92264426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247073.1XP_030102933.1  cryptochrome-2 isoform X2

      Conserved Domains (1) summary
      pfam03441
      Location:129327
      FAD_binding_7; FAD binding domain of DNA photolyase
    2. XM_017315281.3XP_017170770.1  cryptochrome-2 isoform X1

      UniProtKB/Swiss-Prot
      O08706, Q6A024, Q9R194
      Related
      ENSMUSP00000106909.2, ENSMUST00000111278.2
      Conserved Domains (2) summary
      COG0415
      Location:21509
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:306504
      FAD_binding_7; FAD binding domain of DNA photolyase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001113333.1: Suppressed sequence

      Description
      NM_001113333.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.