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    Emc10 ER membrane protein complex subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 69683, updated on 9-Dec-2024

    Summary

    Official Symbol
    Emc10provided by MGI
    Official Full Name
    ER membrane protein complex subunit 10provided by MGI
    Primary source
    MGI:MGI:1916933
    See related
    Ensembl:ENSMUSG00000008140 AllianceGenome:MGI:1916933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Inm02; Mirta22; 2310044H10Rik; 5430410O10Rik
    Summary
    Predicted to contribute to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell migration; and positive regulation of endothelial cell proliferation. Located in extracellular region. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human EMC10 (ER membrane protein complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 166.5), ovary adult (RPKM 122.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Emc10 in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44139361..44145953, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44489937..44496524, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 2 Neighboring gene microRNA 7052 Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene myosin binding protein C, fast-type Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of EMC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ER membrane protein complex subunit 10
    Names
    UPF0510 protein INM02
    hematopoietic signal peptide-containing membrane domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355107.1NP_001342036.1  ER membrane protein complex subunit 10 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC149607
      UniProtKB/TrEMBL
      A0A0X1KG67
      Related
      ENSMUSP00000113141.4, ENSMUST00000118515.9
    2. NM_197991.3NP_932108.3  ER membrane protein complex subunit 10 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC149607
      Consensus CDS
      CCDS52231.2
      UniProtKB/Swiss-Prot
      Q3TAS6, Q3TFU1, Q5UCC3, Q5UCC5, Q8VCD8, Q99JJ8
      UniProtKB/TrEMBL
      A0A0X1KG67
      Related
      ENSMUSP00000113509.4, ENSMUST00000118808.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44139361..44145953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242972.2XP_030098832.1  ER membrane protein complex subunit 10 isoform X1

      UniProtKB/TrEMBL
      A0A0X1KG67
    2. XM_006541176.3XP_006541239.1  ER membrane protein complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      A0A0X1KG67
      Related
      ENSMUSP00000116293.4, ENSMUST00000138328.3

    RNA

    1. XR_003946559.2 RNA Sequence