MAGEA9 MAGE family member A9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAGEA9provided by HGNC
Official Full Name: MAGE family member A9provided by HGNC
Primary source: HGNC:HGNC:6807
See related: Ensembl:ENSG00000123584 MIM:300342; AllianceGenome:HGNC:6807
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT1.9; MAGE9
Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward testis (RPKM 5.4) See more
Orthologs: all
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Genomic context

Location:: Xq28

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (149781877..149787737)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (148047665..148053471)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (148863593..148869399)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation and Migration by Regulating miR-143-3p and MAGE Family Member A9 (MAGEA9) in Oral Squamous Cell Carcinoma.
Title: Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation and Migration by Regulating miR-143-3p and MAGE Family Member A9 (MAGEA9) in Oral Squamous Cell Carcinoma.
MAGE-A9 overexpression promoted cell proliferation, colony formation, migration, chemoresistance, and tumorigenicity in the context of EpCAM+ HCC cells, whereas MAGE-A9 knockdown significantly inhibited anchorage-dependent and spheroid colony formation and in vivo tumorigenicity.
Title: High expression of MAGE-A9 contributes to stemness and malignancy of human hepatocellular carcinoma.
potential X-linked candidate for the CNV67-related spermatogenic failure phenotype
Title: Evidence for the involvement of the proximal copy of the MAGEA9 gene in Xq28-linked CNV67 specific to spermatogenic failure.
The overall survival of laryngeal squamous cell carcinoma patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression.
Title: Expression of MAGE-A1, -A9, -A11 in laryngeal squamous cell carcinoma and their prognostic significance: a retrospective clinical study.
High expression levels of MAGE-A9 are correlated with lung adenocarcinoma.
Title: High expression levels of MAGE-A9 are correlated with unfavorable survival in lung adenocarcinoma.
The results showed that the high expression of MAGE-A9 protein in NSCLC tumor cells were commonly present in squamous cell carcinomas. It was also related to larger tumor diameter, lymph node metastasis and later stage grouping with TNM classification
Title: High expression of MAGE-A9 in tumor and stromal cells of non-small cell lung cancer was correlated with patient poor survival.
These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC patients
Title: High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma.
High expression of MAGE-A9 indicates unfavorable survival outcome in laryngeal squamous cell carcinoma patients.
Title: Expression and prognostic value of MAGE-A9 in laryngeal squamous cell carcinoma.
The data suggest that MAGE-A9 expression is correlated with malignant attributes of invasive ductal breast cancer
Title: Overexpression of MAGE-A9 predicts unfavorable outcome in breast cancer.
MAGE-A9 and MAGE-A11 are tumor-specific antigens and not only DNA hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE-A9 and MAGE-A11 gene silencing.
Title: Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of melanoma antigen family A, 9 (MAGEA9) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC35637 (e-PCR)
- UniSTS:65044

SHGC-35638 (e-PCR)
- UniSTS:57731

GDB:581728 (e-PCR)
- UniSTS:157870

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanoma-associated antigen 9

Names: MAGE-9 antigen; cancer/testis antigen 1.9; cancer/testis antigen family 1, member 9; melanoma antigen family A, 9; melanoma antigen family A9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005365.5 → NP_005356.1 melanoma-associated antigen 9

See identical proteins and their annotated locations for NP_005356.1

Status: REVIEWED

Source sequence(s)

AC244098, BC002351

Consensus CDS

CCDS14691.1

UniProtKB/Swiss-Prot

A8K8A7, P43362, Q7Z5K4, Q92910

Related

ENSP00000243314.5, ENST00000243314.5

Conserved Domains (2) summary

pfam01454
Location:128 → 279

MAGE; MAGE family

pfam12440
Location:5 → 80

MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

149781877..149787737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024452381.2 → XP_024308149.1 melanoma-associated antigen 9 isoform X1

UniProtKB/Swiss-Prot

A8K8A7, P43362, Q7Z5K4, Q92910

Conserved Domains (2) summary

pfam01454
Location:128 → 279

MAGE; MAGE family

pfam12440
Location:5 → 80

MAGE_N; Melanoma associated antigen family N terminal
XM_005262335.4 → XP_005262392.1 melanoma-associated antigen 9 isoform X1

See identical proteins and their annotated locations for XP_005262392.1

UniProtKB/Swiss-Prot

A8K8A7, P43362, Q7Z5K4, Q92910

Conserved Domains (2) summary

pfam01454
Location:128 → 279

MAGE; MAGE family

pfam12440
Location:5 → 80

MAGE_N; Melanoma associated antigen family N terminal
XM_005262334.4 → XP_005262391.1 melanoma-associated antigen 9 isoform X1

See identical proteins and their annotated locations for XP_005262391.1

UniProtKB/Swiss-Prot

A8K8A7, P43362, Q7Z5K4, Q92910

Conserved Domains (2) summary

pfam01454
Location:128 → 279

MAGE; MAGE family

pfam12440
Location:5 → 80

MAGE_N; Melanoma associated antigen family N terminal
XM_024452382.2 → XP_024308150.1 melanoma-associated antigen 9 isoform X1

UniProtKB/Swiss-Prot

A8K8A7, P43362, Q7Z5K4, Q92910

Conserved Domains (2) summary

pfam01454
Location:128 → 279

MAGE; MAGE family

pfam12440
Location:5 → 80

MAGE_N; Melanoma associated antigen family N terminal