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    B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 56386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B4galt6provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6provided by MGI
    Primary source
    MGI:MGI:1928380
    See related
    Ensembl:ENSMUSG00000056124 AllianceGenome:MGI:1928380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide and neurogenesis. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in small intestine adult (RPKM 16.5), duodenum adult (RPKM 16.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B4galt6 in Genome Data Viewer
    Location:
    18 A2; 18 11.48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20817656..20879461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20684599..20746404, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16090 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene transthyretin Neighboring gene STARR-seq mESC enhancer starr_43979 Neighboring gene predicted gene, 31437 Neighboring gene STARR-seq mESC enhancer starr_43980 Neighboring gene STARR-seq mESC enhancer starr_43983 Neighboring gene STARR-seq mESC enhancer starr_43987 Neighboring gene STARR-seq mESC enhancer starr_43988 Neighboring gene trafficking protein particle complex 8 Neighboring gene STARR-positive B cell enhancer ABC_E11655 Neighboring gene STARR-seq mESC enhancer starr_43995 Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene ring finger protein 125 Neighboring gene STARR-seq mESC enhancer starr_43997

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. Nomura T, et al. J Biol Chem, 1998 May 29. PMID 9593693
    2. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. Yoshihara T, et al. PLoS Genet, 2018 Aug. PMID 30114188, Free PMC Article
    3. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Tokuda N, et al. Glycobiology, 2013 Oct. PMID 23882130
    4. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Mayo L, et al. Nat Med, 2014 Oct. PMID 25216636, Free PMC Article
    5. A hypomorphic lsd1 allele results in heart development defects in mice. Nicholson TB, et al. PLoS One, 2013. PMID 23637775, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process via lactosylceramide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lactosylceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 6
    Names
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
    UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
    b4Gal-T6
    beta-1, 4-galactosyltransferase VI
    beta-1,4-GalTase 6
    beta4Gal-T6
    glucosylceramide beta-1,4-galactosyltransferase
    lacCer synthase
    lactosylceramide synthase
    NP_062711.1
    XP_030106406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019737.2 → NP_062711.1  beta-1,4-galactosyltransferase 6

      See identical proteins and their annotated locations for NP_062711.1

      Status: VALIDATED

      Source sequence(s)
      AC129078, AF097158
      Consensus CDS
      CCDS29086.1
      UniProtKB/Swiss-Prot
      Q9WVK5
      UniProtKB/TrEMBL
      Q3UUA9, Q3UUN1
      Related
      ENSMUSP00000066515.6, ENSMUST00000070080.6
      Conserved Domains (1) summary
      cd00899
      Location:155 → 371
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      20817656..20879461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250546.2 → XP_030106406.1  beta-1,4-galactosyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      Q3TPM8, Q3UUN1
      Conserved Domains (1) summary
      cd00899
      Location:111 → 327
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVK5.1 GenPept UniProtKB/Swiss-Prot:Q9WVK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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