Fez1 fasciculation and elongation protein zeta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fez1provided by MGI
Official Full Name: fasciculation and elongation protein zeta 1provided by MGI
Primary source: MGI:MGI:2670976
See related: Ensembl:ENSMUSG00000032118 AllianceGenome:MGI:2670976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UNC76; UNC-76
Summary: Enables gamma-tubulin binding activity. Predicted to be involved in several processes, including negative regulation of autophagosome assembly; positive regulation of anterograde axonal transport of mitochondrion; and positive regulation of neuron projection development. Located in centrosome and cytoplasm. Is expressed in several structures, including brain and spinal cord. Orthologous to human FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 83.7), cerebellum adult (RPKM 71.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.69 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (36732694..36790220)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (36821398..36878926)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of HDAC11 had no obvious impact on brain morphology and neural stem/precursor cells isolated from Hdac11 (KO/KO) mice had comparable proliferation and differentiation characteristics. However, in differentiating neural cells this study observed decreased expression of schizophrenia-associated gene Fez1.
Title: Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.
Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking.
Title: Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Dendrite growth depends on degradation of FEZ1 regulated by Cdc20/APC.
Title: Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system.
Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus.
Title: Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1
Title: Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex.
Title: Fez1 is layer-specifically expressed in the adult mouse neocortex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitochondrion localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of anterograde axonal transport of mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anterograde axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fasciculation and elongation protein zeta-1

Names: zygin I; zygin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357610.1 → NP_001344539.1 fasciculation and elongation protein zeta-1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All six transcripts encode the same protein.

Source sequence(s)

CT009699, CT955982

Consensus CDS

CCDS40581.1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein
NM_001357611.1 → NP_001344540.1 fasciculation and elongation protein zeta-1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

CT009699

Consensus CDS

CCDS40581.1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein
NM_001357612.1 → NP_001344541.1 fasciculation and elongation protein zeta-1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

CT009699, CT955982

Consensus CDS

CCDS40581.1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein
NM_001357613.2 → NP_001344542.1 fasciculation and elongation protein zeta-1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

CT009699

Consensus CDS

CCDS40581.1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein
NM_001357614.1 → NP_001344543.1 fasciculation and elongation protein zeta-1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

CT009699

Consensus CDS

CCDS40581.1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Related

ENSMUSP00000126072.2, ENSMUST00000163816.8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein
NM_001421510.1 → NP_001408439.1 fasciculation and elongation protein zeta-1

Status: VALIDATED

Source sequence(s)

CT009699
NM_183171.6 → NP_898994.2 fasciculation and elongation protein zeta-1

See identical proteins and their annotated locations for NP_898994.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

CT009699

Consensus CDS

CCDS40581.1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Related

ENSMUSP00000034630.9, ENSMUST00000034630.15

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

36732694..36790220

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244292.2 → XP_030100152.1 fasciculation and elongation protein zeta-1 isoform X1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein
XM_030244293.2 → XP_030100153.1 fasciculation and elongation protein zeta-1 isoform X1

UniProtKB/Swiss-Prot

Q3YE74, Q8K0X8

Conserved Domains (1) summary

pfam07763
Location:58 → 297

FEZ; FEZ-like protein