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    Adgrf4 adhesion G protein-coupled receptor F4 [ Mus musculus (house mouse) ]

    Gene ID: 78249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrf4provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F4provided by MGI
    Primary source
    MGI:MGI:1925499
    See related
    Ensembl:ENSMUSG00000023918 AllianceGenome:MGI:1925499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr115; 4632435A09Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Is expressed in several structures, including genitourinary system; heart; lung; skin; and thymus. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 1.5), stomach adult (RPKM 1.3) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrf4 in Genome Data Viewer
    Location:
    17 B3; 17 19.65 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (42967099..43008460, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42656208..42697569, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42562 Neighboring gene STARR-seq mESC enhancer starr_42563 Neighboring gene STARR-seq mESC enhancer starr_42564 Neighboring gene STARR-seq mESC enhancer starr_42565 Neighboring gene STARR-seq mESC enhancer starr_42566 Neighboring gene patched domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_42567 Neighboring gene STARR-seq mESC enhancer starr_42568 Neighboring gene STARR-seq mESC enhancer starr_42569 Neighboring gene opsin 5 Neighboring gene STARR-seq mESC enhancer starr_42570 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene STARR-positive B cell enhancer mm9_chr17:42919148-42919448 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene CD2-associated protein Neighboring gene STARR-seq mESC enhancer starr_42571 Neighboring gene STARR-positive B cell enhancer ABC_E9167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. Chiba Y, et al. J Biol Chem, 2020 Nov 6. PMID 32868297, Free PMC Article
    2. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Prömel S, et al. Dev Dyn, 2012 Oct. PMID 22837050
    3. Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4). Lu S, et al. PLoS One, 2017. PMID 28806758, Free PMC Article
    4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts.
      Title: G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107333, MGC175941

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pharyngeal arch artery morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor F4
    Names
    G protein coupled receptor Gpr115
    G protein-coupled receptor 115
    probable G-protein coupled receptor 115

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289499.1 → NP_001276428.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_001276428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, BY714064, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q5FW81, Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Related
      ENSMUSP00000132890.2, ENSMUST00000167993.8
      Conserved Domains (3) summary
      cd14964
      Location:405 → 429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351 → 394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402 → 669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001289500.1 → NP_001276429.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_001276429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, BY714064, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q5FW81, Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Related
      ENSMUSP00000133261.2, ENSMUST00000170723.8
      Conserved Domains (3) summary
      cd14964
      Location:405 → 429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351 → 394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402 → 669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001289501.1 → NP_001276430.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_001276430.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, BY142177, BY714064, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q5FW81, Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Conserved Domains (3) summary
      cd14964
      Location:405 → 429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351 → 394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402 → 669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. NM_030067.2 → NP_084343.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_084343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q5FW81, Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Related
      ENSMUSP00000024711.5, ENSMUST00000024711.11
      Conserved Domains (3) summary
      cd14964
      Location:405 → 429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351 → 394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402 → 669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      42967099..43008460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317725.2 → XP_017173214.1  adhesion G protein-coupled receptor F4 isoform X1

      UniProtKB/Swiss-Prot
      Q5FW81, Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Conserved Domains (3) summary
      cd14964
      Location:405 → 429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351 → 394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402 → 669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2L6.2 GenPept UniProtKB/Swiss-Prot:Q9D2L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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