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    Hnrnpr heterogeneous nuclear ribonucleoprotein R [ Mus musculus (house mouse) ]

    Gene ID: 74326, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnprprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Rprovided by MGI
    Primary source
    MGI:MGI:1891692
    See related
    Ensembl:ENSMUSG00000066037 AllianceGenome:MGI:1891692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpr; 2610003J05Rik; 2610528B01Rik
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA destabilization. Located in nucleus. Is expressed in central nervous system; jaw; limb; sensory organ; and thymus. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 17.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnrnpr in Genome Data Viewer
    Location:
    4 D3; 4 68.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136038230..136086758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136310942..136345981)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene zinc finger protein 46 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis. Zare A, et al. Nat Commun, 2024 Aug 28. PMID 39198412, Free PMC Article
    2. hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons. Briese M, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507242, Free PMC Article
    3. Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr. Salehi S, et al. Nat Commun, 2023 Jul 12. PMID 37438340, Free PMC Article
    4. Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin. Ghanawi H, et al. Nucleic Acids Res, 2021 Dec 2. PMID 34850154, Free PMC Article
    5. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. Fukuda A, et al. PLoS One, 2013. PMID 23967313, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.
      Title: hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.
    2. Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.
      Title: Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.
    3. HnRNP R shapes the axonal transcriptome and its activity toward RNA localization is intricately linked to its main binding partner, noncoding RNA 7SK.
      Title: hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons.
    4. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene.
      Title: Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene.
    5. HnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation.
      Title: The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277121.1 → NP_001264050.1  heterogeneous nuclear ribonucleoprotein R isoform a

      See identical proteins and their annotated locations for NP_001264050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK152039, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3UMT8, Q8VHM5
      Related
      ENSMUSP00000101476.2, ENSMUST00000105850.8
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    2. NM_001277122.1 → NP_001264051.1  heterogeneous nuclear ribonucleoprotein R isoform b

      See identical proteins and their annotated locations for NP_001264051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK133840, AK138916, AL670673, AL935264, AW060625, BX537311, BY311081
      Consensus CDS
      CCDS71495.1
      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Related
      ENSMUSP00000081239.6, ENSMUST00000084219.12
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    3. NM_001277123.1 → NP_001264052.1  heterogeneous nuclear ribonucleoprotein R isoform b

      See identical proteins and their annotated locations for NP_001264052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK138916, AK145849, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS71495.1
      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Related
      ENSMUSP00000138263.2, ENSMUST00000131671.8
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    4. NM_001355182.1 → NP_001342111.1  heterogeneous nuclear ribonucleoprotein R isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK152039, AL670673, AL935264, AW060625, BB841005, BX537311, BY138716
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3UMT8, Q8VHM5
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    5. NM_028871.2 → NP_083147.1  heterogeneous nuclear ribonucleoprotein R isoform a

      See identical proteins and their annotated locations for NP_083147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK145849, AK147043, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3UMT8, Q8VHM5
      Related
      ENSMUSP00000138399.2, ENSMUST00000148843.10
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136038230..136086758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539228.5 → XP_006539291.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539291.1

      UniProtKB/TrEMBL
      Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    2. XM_006539222.3 → XP_006539285.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539285.1

      UniProtKB/TrEMBL
      Q3UMT8
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    3. XM_036164497.1 → XP_036020390.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    4. XM_006539223.5 → XP_006539286.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539286.1

      UniProtKB/TrEMBL
      Q3UMT8
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    5. XM_030253846.2 → XP_030109706.1  heterogeneous nuclear ribonucleoprotein R isoform X2

      UniProtKB/TrEMBL
      Q3UMT8, Q8VHM5
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    6. XM_030253848.2 → XP_030109708.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      UniProtKB/TrEMBL
      Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    7. XM_030253850.2 → XP_030109710.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    8. XM_006539226.3 → XP_006539289.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539289.1

      UniProtKB/TrEMBL
      Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    9. XM_006539227.2 → XP_006539290.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539290.1

      UniProtKB/TrEMBL
      Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    10. XM_006539225.5 → XP_006539288.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539288.1

      UniProtKB/TrEMBL
      Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    11. XM_030253849.2 → XP_030109709.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    12. XM_036164499.1 → XP_036020392.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    13. XM_006539224.5 → XP_006539287.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539287.1

      UniProtKB/TrEMBL
      Q3UMT8
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37 → 106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    14. XM_036164498.1 → XP_036020391.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      UniProtKB/TrEMBL
      F7B5B5, Q99KG1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    RNA

    1. XR_004941997.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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