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    MCH1 Mch1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCH1
    Official Full Name
    Mch1p
    Primary source
    SGD:S000002212
    Locus tag
    YDL054C
    See related
    AllianceGenome:SGD:S000002212; FungiDB:YDL054C; VEuPathDB:YDL054C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MCH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (359825..361285, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene tRNA-Lys Neighboring gene Pbp4p Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase SLC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
    2. A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. McLaughlin JE, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 20007368, Free PMC Article
    3. Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Matsumoto R, et al. Protoplasma, 2013 Dec. PMID 23708375
    4. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596
    5. Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Menon BB, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15817685, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mch1p
    NP_010229.1
    • Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      359825..361285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180113.1 → NP_010229.1  TPA: Mch1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRU2, Q07376
      UniProtKB/TrEMBL
      B3LGV2, B5VFL3, C8Z4L5, N1PAA3
      Conserved Domains (1) summary
      cd17314
      Location:27 → 465
      MFS_MCT_like; Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07376.1

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