SOR2 L-iditol 2-dehydrogenase SOR2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SOR2
Official Full Name: L-iditol 2-dehydrogenase SOR2
Primary source: SGD:S000002405
Locus tag: YDL246C
See related: AllianceGenome:SGD:S000002405; FungiDB:YDL246C; VEuPathDB:YDL246C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-iditol 2-dehydrogenase (NAD+) activity. Predicted to be involved in hexose metabolic process and sorbitol catabolic process. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SOR2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (8683..9756, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables D-xylulose reductase activity	IEA Inferred from Electronic Annotation more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in hexose metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sorbitol catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

Go to the top of the page Help

Preferred Names: L-iditol 2-dehydrogenase SOR2

NP_010035.1

EC 1.1.1.9

Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

8683..9756 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180306.1 → NP_010035.1 TPA: L-iditol 2-dehydrogenase SOR2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010035.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRB1, Q07786

UniProtKB/TrEMBL

A6ZX89, C8Z6M7, N1PAA8

Conserved Domains (1) summary

cd05285
Location:8 → 353

sorbitol_DH; Sorbitol dehydrogenase