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    EMC2 Emc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC2
    Official Full Name
    Emc2p
    Primary source
    SGD:S000003848
    Locus tag
    YJR088C
    See related
    AllianceGenome:SGD:S000003848; FungiDB:YJR088C; VEuPathDB:YJR088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum and nucleus. Part of EMC complex. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMC2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (586495..587373, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tmh11p Neighboring gene Ste18p Neighboring gene survivin Neighboring gene SCF ubiquitin ligase complex subunit GRR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    2. ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. Xiao T, et al. Life Sci Alliance, 2021 Mar. PMID 33479049, Free PMC Article
    3. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
    4. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
    5. Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast. Medkour Y, et al. Oncotarget, 2019 Oct 8. PMID 31645900, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Emc2p
    NP_012621.1
    • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      586495..587373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181745.1 → NP_012621.1  TPA: Emc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWQ6, P47133, Q66R61
      UniProtKB/TrEMBL
      A6ZQ43, B3LQH2, B5VLN5, C7GMB9, C8ZBN4, N1P062
      Conserved Domains (1) summary
      sd00006
      Location:163 → 191
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47133.1

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