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    THI73 Thi73p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI73
    Official Full Name
    Thi73p
    Primary source
    SGD:S000003994
    Locus tag
    YLR004C
    See related
    AllianceGenome:SGD:S000003994; FungiDB:YLR004C; VEuPathDB:YLR004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI73 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (157934..159505, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Noc3p Neighboring gene Cms1p Neighboring gene TFIIH/NER complex subunit SSL1 Neighboring gene mitogen-activated protein kinase kinase kinase SSK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. Paulsen IT, et al. FEBS Lett, 1998 Jun 23. PMID 9678606
    2. Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). Llorente B, et al. FEBS Lett, 2000 Jun 23. PMID 10869563
    3. Genome-wide responses to mitochondrial dysfunction. Epstein CB, et al. Mol Biol Cell, 2001 Feb. PMID 11179416, Free PMC Article
    4. Ammonia pulses and metabolic oscillations guide yeast colony development. Palková Z, et al. Mol Biol Cell, 2002 Nov. PMID 12429834, Free PMC Article
    5. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita D, et al. Mol Genet Genomics, 2006 Aug. PMID 16850348

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thi73p
    NP_013104.1
    • Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      157934..159505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181891.1 → NP_013104.1  TPA: Thi73p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY06, Q07904
      UniProtKB/TrEMBL
      A7A0Q9, B3LTG9, C7GPF4, C8ZCX6, G2WIJ8, N1NYZ1
      Conserved Domains (1) summary
      cd17327
      Location:77 → 481
      MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07904.1

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