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    LINC02210-CRHR1 LINC02210-CRHR1 readthrough [ Homo sapiens (human) ]

    Gene ID: 104909134, updated on 4-Jan-2025

    Summary

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    Official Symbol
    LINC02210-CRHR1provided by HGNC
    Official Full Name
    LINC02210-CRHR1 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:51483
    See related
    Ensembl:ENSG00000263715 AllianceGenome:HGNC:51483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC57346-CRHR1; CRHR1-IT1-CRHR1
    Summary
    This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]
    Expression
    Broad expression in brain (RPKM 3.0), testis (RPKM 2.3) and 23 other tissues See more
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    Genomic context

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    See LINC02210-CRHR1 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45620346..45835828)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (46482030..46697461)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43697712..43913194)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43677957-43678654 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43695849-43696828 Neighboring gene ribosomal protein S26 pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 2210 Neighboring gene uncharacterized LOC105371802 Neighboring gene ARF GTPase 2, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:43782244-43783443 Neighboring gene Sharpr-MPRA regulatory region 9533 Neighboring gene uncharacterized LOC107985028 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43823543-43824208 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43822876-43823542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43828999-43829910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43835142-43835642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43840160-43840660 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43848965-43849573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43862413-43862913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43869433-43869933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43883739-43884240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43884241-43884740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43890849-43891705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43900915-43901416 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43917814-43918023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43922169-43923153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43923154-43924137 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43971863-43972748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43972749-43973634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43974521-43975405 Neighboring gene MAPT intronic transcript 1 Neighboring gene microtubule associated protein tau

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Human protein factory for converting the transcriptome into an in vitro-expressed proteome, Goshima N, et al. Nat Methods, 2008 Dec. PMID 19054851
    2. The genomic organization of the human corticotropin-releasing factor type-1 receptor. Sakai K, et al. Gene, 1998 Sep 28. PMID 9757017
    3. Structure of class B GPCR corticotropin-releasing factor receptor 1. Hollenstein K, et al. Nature, 2013 Jul 25. PMID 23863939
    4. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. Pioszak AA, et al. J Biol Chem, 2008 Nov 21. PMID 18801728, Free PMC Article
    5. Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels. Tao J, et al. Mol Pharmacol, 2008 Jun. PMID 18292205

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Clone Names

    • FLJ60266, FLJ60308

    General protein information

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    Preferred Names
    CRHR1-IT1-CRHR1 protein
    Names
    CRHR1-IT1-CRHR1 readthrough

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256299.3 → NP_001243228.1  CRHR1-IT1-CRHR1 protein isoform 5

      See identical proteins and their annotated locations for NP_001243228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains alternate 5' exon structure, and it thus differs in the 5' UTR, initiates translation at a downstream in-frame start codon, and it also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 6. The encoded isoform (5) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 6.
      Source sequence(s)
      AC217771, FJ543100
      Related
      ENSP00000488912.1, ENST00000634540.1
      Conserved Domains (2) summary
      cd14964
      Location:14 → 40
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 205
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001303016.1 → NP_001289945.1  CRHR1-IT1-CRHR1 protein isoform 6

      See identical proteins and their annotated locations for NP_001289945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes the longer isoform (6).
      Source sequence(s)
      AC217771, AK297590, FJ543100
      UniProtKB/TrEMBL
      B4DMR5
      Conserved Domains (1) summary
      pfam00002
      Location:15 → 212
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      45620346..45835828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      952322..1168458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      322470..537950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      46482030..46697461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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