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    FKS3 putative 1,3-beta-D-glucan synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FKS3
    Official Full Name
    putative 1,3-beta-D-glucan synthase
    Primary source
    SGD:S000004923
    Locus tag
    YMR306W
    See related
    AllianceGenome:SGD:S000004923; FungiDB:YMR306W; VEuPathDB:YMR306W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 1,3-beta-D-glucan synthase activity. Involved in ascospore wall assembly. Located in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FKS3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (881159..886516)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP15 Neighboring gene putative family 17 glucosidase Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene importin PSE1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mazur P, et al. Mol Cell Biol, 1995 Oct. PMID 7565718, Free PMC Article
    2. Cell wall synthesis specific cytocidal effect of Hansenula mrakii toxin-1 on Saccharomyces cerevisiae. Takasuka T, et al. Cell Mol Biol Res, 1995. PMID 8777437
    3. A microtiter-based fluorescence assay for (1,3)-beta-glucan synthases. Shedletzky E, et al. Anal Biochem, 1997 Jun 15. PMID 9193713
    4. Inhibition of yeast (1,3)-beta-glucan synthase by phospholipase A2 and its reaction products. Ko YT, et al. Biochim Biophys Acta, 1994 Jul 13. PMID 8038192
    5. The MAPK homolog, Smk1, promotes assembly of the glucan layer of the spore wall in S. cerevisiae. Lee-Soety JY, et al. Yeast, 2024 Jul. PMID 38874213,

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,3-beta-D-glucan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->3)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (1->3)-beta-D-glucan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 1,3-beta-D-glucan synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative 1,3-beta-D-glucan synthase
    NP_014036.1
    • Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      881159..886516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182817.1 → NP_014036.1  TPA: putative 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0D3, Q04952
      UniProtKB/TrEMBL
      B3LMJ4, C7GPV7, C8ZFH5, G2WL15, N1NZ80
      Conserved Domains (2) summary
      pfam02364
      Location:694 → 1542
      Glucan_synthase; 1,3-beta-glucan synthase component
      pfam14288
      Location:182 → 290
      FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04952.1

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