Ivns1abp influenza virus NS1A binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ivns1abpprovided by MGI
Official Full Name: influenza virus NS1A binding proteinprovided by MGI
Primary source: MGI:MGI:2152389
See related: Ensembl:ENSMUSG00000023150 AllianceGenome:MGI:2152389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ND1; NS-1; Nd1-L; Nd1-S; NS1-BP; HSPC068; mKIAA0850; 1190004M08Rik; 1700126I16Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 79.1), CNS E11.5 (RPKM 71.2) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 G1; 1 64.06 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (151220237..151240196)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (151344486..151364445)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1.
Title: Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1.
Overexpression of short variant form of new Kelch family protein ND1 leads to erythroid and megakaryocyte dysplasia by targeting megakaryocyte-erythroid progenitors.
Title: Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors.
Nd1-L is involved in invasion and metastasis of cancer cells by regulating the actin cytoskeleton and Rho family proteins.
Title: A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism.
Nd1-S may play a role in cell cycle progression in the nucleus.
Title: Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts.
Nd1-L functions as a stabilizer of actin filaments as an actin-binding protein and may play a role in the dynamic organization of the actin cytoskeleton
Title: Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments.
Plays a critical role in protecting the heart from doxorubicin-induced cardiomyopathy.
Title: Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI132432 (e-PCR)
- UniSTS:207212

AA960440 (e-PCR)
- UniSTS:158865

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: influenza virus NS1A-binding protein homolog

Names: ND1-L2; NS1-binding protein homolog; kelch family protein Nd1; kelch family protein Nd1-L

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039511.1 → NP_001034600.1 influenza virus NS1A-binding protein homolog isoform 1

See identical proteins and their annotated locations for NP_001034600.1

Status: VALIDATED

Source sequence(s)

AC115060, AK007291, AL355706

Consensus CDS

CCDS35735.1

UniProtKB/Swiss-Prot

Q920Q8

Related

ENSMUSP00000107518.4, ENSMUST00000111887.10

Conserved Domains (2) summary

cd18306
Location:14 → 137

BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)

cd18502
Location:129 → 221

BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)
NM_001039512.1 → NP_001034601.1 influenza virus NS1A-binding protein homolog isoform 3

See identical proteins and their annotated locations for NP_001034601.1

Status: VALIDATED

Source sequence(s)

AC115060, AK144835, AL355706

Consensus CDS

CCDS15358.1

UniProtKB/Swiss-Prot

Q920Q8

Related

ENSMUSP00000095150.2, ENSMUST00000097543.8

Conserved Domains (6) summary

smart00612
Location:472 → 517

Kelch; Kelch domain

PHA03098
Location:23 → 596

PHA03098; kelch-like protein; Provisional

cd14735
Location:129 → 181

BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins

sd00038
Location:460 → 503

Kelch; KELCH repeat [structural motif]

pfam00651
Location:22 → 126

BTB; BTB/POZ domain

pfam01344
Location:553 → 593

Kelch_1; Kelch motif
NM_001359262.1 → NP_001346191.1 influenza virus NS1A-binding protein homolog isoform 4

Status: VALIDATED

Source sequence(s)

AC165946

Conserved Domains (3) summary

sd00038
Location:460 → 503

Kelch; KELCH repeat [structural motif]

pfam01344
Location:553 → 593

Kelch_1; Kelch motif

cl28614
Location:3 → 549

BTB; Broad-Complex, Tramtrack and Bric a brac
NM_001359263.1 → NP_001346192.1 influenza virus NS1A-binding protein homolog isoform 5

Status: VALIDATED

Source sequence(s)

AC165946

UniProtKB/TrEMBL

Q06BK5

Conserved Domains (3) summary

smart00612
Location:88 → 134

Kelch; Kelch domain

PHA03098
Location:136 → 357

PHA03098; kelch-like protein; Provisional

sd00038
Location:221 → 264

Kelch; KELCH repeat [structural motif]
NM_054102.2 → NP_473443.2 influenza virus NS1A-binding protein homolog isoform 2

See identical proteins and their annotated locations for NP_473443.2

Status: VALIDATED

Source sequence(s)

AC115060, AK146494, AL355706

Consensus CDS

CCDS15359.1

UniProtKB/Swiss-Prot

Q06BK6, Q3TXI1, Q3UJE3, Q3UJS1, Q3UKH9, Q3UMK9, Q6ZQ34, Q920Q8, Q99KN0, Q9D978

Related

ENSMUSP00000023918.7, ENSMUST00000023918.13

Conserved Domains (3) summary

sd00038
Location:502 → 545

Kelch; KELCH repeat [structural motif]

pfam01344
Location:595 → 635

Kelch_1; Kelch motif

cl28614
Location:23 → 591

BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

151220237..151240196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529089.4 → XP_006529152.1 influenza virus NS1A-binding protein homolog isoform X1

Conserved Domains (3) summary

smart00612
Location:209 → 255

Kelch; Kelch domain

PHA03098
Location:257 → 478

PHA03098; kelch-like protein; Provisional

sd00038
Location:342 → 385

Kelch; KELCH repeat [structural motif]
XM_030243144.1 → XP_030099004.1 influenza virus NS1A-binding protein homolog isoform X1

Conserved Domains (3) summary

smart00612
Location:209 → 255

Kelch; Kelch domain

PHA03098
Location:257 → 478

PHA03098; kelch-like protein; Provisional

sd00038
Location:342 → 385

Kelch; KELCH repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028582.2: Suppressed sequence

Description

NM_028582.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.