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    Lbx1 ladybird homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 16814, updated on 4-Jan-2025

    Summary

    Official Symbol
    Lbx1provided by MGI
    Official Full Name
    ladybird homeobox 1provided by MGI
    Primary source
    MGI:MGI:104867
    See related
    Ensembl:ENSMUSG00000025216 AllianceGenome:MGI:104867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lbx1h
    Summary
    Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including heart looping; negative regulation of glutamatergic neuron differentiation; and neuron differentiation. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; skeletal musculature; and urinary system. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human LBX1 (ladybird homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in CNS E14 (RPKM 1.3), cerebellum adult (RPKM 1.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Lbx1 in Genome Data Viewer
    Location:
    19 C3; 19 38.61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45221123..45225280, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45232684..45236841, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35923 Neighboring gene T cell leukemia, homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_46263 Neighboring gene STARR-seq mESC enhancer starr_46264 Neighboring gene STARR-seq mESC enhancer starr_46267 Neighboring gene predicted gene 29595 Neighboring gene STARR-seq mESC enhancer starr_46272 Neighboring gene predicted gene 28578

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of glutamatergic neuron differentiation PubMed 
    acts_upstream_of_or_within heart looping PubMed 
    involved_in muscle organ development  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within negative regulation of glutamatergic neuron differentiation PubMed 
    acts_upstream_of_or_within neuron fate commitment PubMed 
    acts_upstream_of_or_within neuron fate determination PubMed 
    acts_upstream_of_or_within neuron fate determination PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    transcription factor LBX1
    Names
    lady bird-like homeobox 1 homolog
    ladybird homeobox protein homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010691.6NP_034821.2  transcription factor LBX1

      Status: VALIDATED

      Source sequence(s)
      AC123058
      Consensus CDS
      CCDS29859.1
      UniProtKB/Swiss-Prot
      P52955, Q3UN09, Q80XA3
      Related
      ENSMUSP00000096997.5, ENSMUST00000099401.6
      Conserved Domains (1) summary
      pfam00046
      Location:128182
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45221123..45225280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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