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    Eef1akmt1 EEF1A alpha lysine methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eef1akmt1provided by MGI
    Official Full Name
    EEF1A alpha lysine methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1915293
    See related
    Ensembl:ENSMUSG00000021951 AllianceGenome:MGI:1915293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N6amt2; Ayu21-96; GtAyu21-96; 2510005D08Rik; Gt(pU21)96Imeg
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytoplasm. Orthologous to human EEF1AKMT1 (EEF1A lysine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 13.2), placenta adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eef1akmt1 in Genome Data Viewer
    Location:
    14 C3; 14 30.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57787052..57809039, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57549595..57571582, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene STARR-positive B cell enhancer ABC_E5444 Neighboring gene STARR-positive B cell enhancer mm9_chr14:58144327-58144627 Neighboring gene STARR-seq mESC enhancer starr_36808 Neighboring gene interleukin 17D Neighboring gene RIKEN cDNA 1700039M10 gene Neighboring gene STARR-positive B cell enhancer ABC_E5445 Neighboring gene exportin 4 Neighboring gene STARR-seq mESC enhancer starr_36813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EEF1A lysine methyltransferase 1
    Names
    Gt(Ayu21)96Imeg
    N-6 adenine-specific DNA methyltransferase 2 (putative)
    eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
    n(6)-adenine-specific DNA methyltransferase 2
    protein-lysine N-methyltransferase N6amt2
    NP_080802.2
    XP_006519546.1
    XP_036014727.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026526.3 → NP_080802.2  EEF1A lysine methyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC154675
      Consensus CDS
      CCDS27157.2
      UniProtKB/Swiss-Prot
      Q9CQR0, Q9CY45
      UniProtKB/TrEMBL
      A0A0D2X7Z2
      Related
      ENSMUSP00000159159.2, ENSMUST00000239099.2
      Conserved Domains (1) summary
      pfam10237
      Location:49 → 161
      N6-adenineMlase; Probable N6-adenine methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      57787052..57809039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158834.1 → XP_036014727.1  EEF1A lysine methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CQR0, Q9CY45
      UniProtKB/TrEMBL
      A0A0D2X7Z2
      Conserved Domains (1) summary
      pfam10237
      Location:49 → 161
      N6-adenineMlase; Probable N6-adenine methyltransferase

    2. XM_006519483.4 → XP_006519546.1  EEF1A lysine methyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006519546.1

      UniProtKB/Swiss-Prot
      Q9CQR0, Q9CY45
      UniProtKB/TrEMBL
      A0A0D2X7Z2
      Conserved Domains (1) summary
      pfam10237
      Location:49 → 161
      N6-adenineMlase; Probable N6-adenine methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY45.1 GenPept UniProtKB/Swiss-Prot:Q9CY45

    Gene LinkOut

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