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    SPT20 Spt20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPT20
    Official Full Name
    Spt20p
    Primary source
    SGD:S000005508
    Locus tag
    YOL148C
    See related
    AllianceGenome:SGD:S000005508; FungiDB:YOL148C; VEuPathDB:YOL148C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADA5
    Summary
    Enables transcription coregulator activity. Involved in IRE1-mediated unfolded protein response and chromatin organization. Part of SAGA complex and SLIK (SAGA-like) complex. Orthologous to human SUPT20H (SPT20 homolog, SAGA complex component); SUPT20HL1 (SUPT20H like 1); and SUPT20HL2 (SUPT20H like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPT20 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (45760..47574, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene methylglyoxal reductase (NADPH-dependent) GRE2 Neighboring gene Dcp1p Neighboring gene Pex11p Neighboring gene DNA replication protein PSF3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription. Marcus GA, et al. Mol Cell Biol, 1996 Jun. PMID 8649430, Free PMC Article
    2. SPT20/ADA5 encodes a novel protein functionally related to the TATA-binding protein and important for transcription in Saccharomyces cerevisiae. Roberts SM, et al. Mol Cell Biol, 1996 Jun. PMID 8649431, Free PMC Article
    3. Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity. Baptista T, et al. J Vis Exp, 2018 Oct 22. PMID 30394386, Free PMC Article
    4. The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. Dudley AM, et al. Genes Dev, 1999 Nov 15. PMID 10580001, Free PMC Article
    5. Involvement of the SAGA and TFIID coactivator complexes in transcriptional dysregulation caused by the separation of core and tail Mediator modules. Saleh MM, et al. G3 (Bethesda), 2022 Dec 1. PMID 36331351, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA histone acetyltransferase complexes. SAGA mRNAs encoding a core set of SAGA subunits are tethered together for co-translational assembly of the encoded proteins.
      Title: Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.
    2. Spt20 regulated the stability of the septin ring and was required for the recruitment of Mid2.
      Title: Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex.
    3. SAGA-TBP binding involves a network of interactions between subunits Spt3, Spt8, Spt20, and Spt7.
      Title: Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spt20p
    NP_014493.1
    • Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      45760..47574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183402.1 → NP_014493.1  TPA: Spt20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014493.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1S1, P50875
      UniProtKB/TrEMBL
      C8ZHG9, G2WM90
      Conserved Domains (1) summary
      pfam12090
      Location:124 → 341
      Spt20; Spt20 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50875.1

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