Nmb neuromedin B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nmbprovided by RGD
Official Full Name: neuromedin Bprovided by RGD
Primary source: RGD:1562710
See related: EnsemblRapid:ENSRNOG00000011011 AllianceGenome:RGD:1562710
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562710
Summary: Enables neuromedin B receptor binding activity. Involved in several processes, including arachidonate secretion; positive regulation of cytosolic calcium ion concentration; and regulation of hormone secretion. Predicted to be located in extracellular space. Predicted to be active in neuron projection. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMB (neuromedin B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 6.1), Thymus (RPKM 3.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144278678..144290523, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (134869446..134875507, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (142721263..142724646, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMB stimulates the reproductive axis in male rats.
Title: Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats.
The expression of NMU mRNA in the female rat pituitary is reduced as the rats develop from the pubertal to the mature period. Additionally, the reduction of pituitary NMU is related to the increases in estradiol and insulin that occur during puberty.
Title: Estradiol suppresses NMU mRNA expression during sexual maturation in the female rat pituitary.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuromedin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuromedin B receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Leydig cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in arachidonate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of testosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of itch	ISO Inferred from Sequence Orthology more info
involved_in sneeze reflex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.