Fbxo8 F-box protein 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbxo8provided by RGD
Official Full Name: F-box protein 8provided by RGD
Primary source: RGD:1307596
See related: EnsemblRapid:ENSRNOG00000010502 AllianceGenome:RGD:1307596
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 133.3), Kidney (RPKM 131.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (38676011..38721849, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (33665305..33711215, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (37131566..37177033, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012050.1 → NP_001012050.1 F-box only protein 8

See identical proteins and their annotated locations for NP_001012050.1

Status: PROVISIONAL

Source sequence(s)

BC088452

UniProtKB/TrEMBL

A0A0G2K0C3, A6KIX1, F1M701, Q5M7U1

Related

ENSRNOP00000071387.1, ENSRNOT00000084469.3

Conserved Domains (2) summary

cd00171
Location:133 → 312

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

pfam12937
Location:74 → 112

F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

38676011..38721849 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275410.1 → XP_063131480.1 F-box only protein 8 isoform X2
XM_063275408.1 → XP_063131478.1 F-box only protein 8 isoform X1

UniProtKB/TrEMBL

A0A0G2K0C3, A6KIX1, F1M701, Q5M7U1
XM_063275409.1 → XP_063131479.1 F-box only protein 8 isoform X1

UniProtKB/TrEMBL

A0A0G2K0C3, A6KIX1, F1M701, Q5M7U1
XM_063275411.1 → XP_063131481.1 F-box only protein 8 isoform X3
XM_039094500.2 → XP_038950428.1 F-box only protein 8 isoform X3

Conserved Domains (1) summary

cd00171
Location:1 → 155

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_063275412.1 → XP_063131482.1 F-box only protein 8 isoform X4

UniProtKB/TrEMBL

A0A8J8Y1I3, A6KIX4