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    Klf1 KLF transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304666, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klf1provided by RGD
    Official Full Name
    KLF transcription factor 1provided by RGD
    Primary source
    RGD:1309398
    See related
    EnsemblRapid:ENSRNOG00000003443 AllianceGenome:RGD:1309398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin binding activity. Involved in cellular response to peptide and maternal process involved in female pregnancy. Predicted to be located in chromatin and nucleoplasm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (KLF transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 271.7) and Lung (RPKM 11.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klf1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40155476..40158651, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23250627..23253802, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26016289..26019557)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene microRNA 3550 Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Qian Z, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12417757, Free PMC Article
    2. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Drissen R, et al. Genes Dev, 2004 Oct 15. PMID 15489291, Free PMC Article
    3. A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia. Arnaud L, et al. Am J Hum Genet, 2010 Nov 12. PMID 21055716, Free PMC Article
    4. Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model. Heruth DP, et al. Genomics, 2010 Nov. PMID 20691777, Free PMC Article
    5. Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Borg J, et al. Nat Genet, 2010 Sep. PMID 20676099, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 1
    Names
    Kruppel like factor 1
    Kruppel-like factor 1 (erythroid)
    erythroid Kruppel-like factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107164.1 → NP_001100634.1  Krueppel-like factor 1

      See identical proteins and their annotated locations for NP_001100634.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IY63, B0BNN2
      Related
      ENSRNOP00000004601.6, ENSRNOT00000004601.7
      Conserved Domains (6) summary
      COG5048
      Location:297 → 375
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:293 → 317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain
      pfam16832
      Location:40 → 65
      EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
      pfam16833
      Location:81 → 103
      EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40155476..40158651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255254.5 → XP_006255316.1  Krueppel-like factor 1 isoform X1

      UniProtKB/TrEMBL
      B0BNN2
      Conserved Domains (6) summary
      COG5048
      Location:297 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:293 → 317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:344 → 369
      zf-H2C2_2; Zinc-finger double domain
      pfam16832
      Location:40 → 65
      EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
      pfam16833
      Location:81 → 103
      EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2
    Nucleotide Protein Strain
    Heading Accession and Version

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