Slc16a1 solute carrier family 16 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc16a1provided by RGD
Official Full Name: solute carrier family 16 member 1provided by RGD
Primary source: RGD:3690
See related: EnsemblRapid:ENSRNOG00000019996 AllianceGenome:RGD:3690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MCT1; RNMCT1; RATMCT1
Summary: Enables identical protein binding activity; lactate:proton symporter activity; and organic cyclic compound binding activity. Involved in cellular response to organic cyclic compound; plasma membrane lactate transport; and pyruvate transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 1100.1), Thymus (RPKM 589.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (194805556..194832966)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (192123755..192144617)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (207108552..207129352)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Title: Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats.
Title: Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats.
The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal muscles.
Title: The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles.
Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions.
Title: Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions.
7ACC2 is an inhibitor of mitochondrial pyruvate transport; the blockade of pyruvate import into mitochondria prevents extracellular lactate uptake as efficiently as a MCT1 inhibitor
Title: Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
Following cerebral ischemia, monocarboxylate transporter 1 (MCT1) expression was upregulated in the peri-infarct striatum but not in the cortex of the brain. In vitro ischemia models were used to induce oligodendrocyte stress as well. An increase in MCT1 expression was detected in oligodendrocyte precursor cells after a mild oxygen-glucose deprivation.
Title: Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses.
The MCT1 mRNA and membrane protein expression varied with estrous cycle stage, with OVX females having higher expression than males, indicating that female sex hormones may play a role in MCT1 regulation.
Title: Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking.
Our results are proposing that in the developing brain white matter, MCT1 is predominately expressed in oligodendrocyte though it mainly expressed in astrocyte in early postnatal, which indicate that MCT1 may involve in the oligodendrocyte development and myelination.
Title: Postnatal alteration of monocarboxylate transporter 1 expression in the rat corpus callosum.
Decreased expression of MCT1/4 in distal airway epithelium may disrupt lung branching morphogenesis and thus contribute to the development of pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model.
Title: Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia.
The transport mechanism of 4-PBA from blood to brain across the BBB likely involves MCT1.
Title: In Vivo and In Vitro Evidence for Brain Uptake of 4-Phenylbutyrate by the Monocarboxylate Transporter 1 (MCT1).

Submit: New GeneRIF Correction See all GeneRIFs (55)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI294019 (e-PCR)
- UniSTS:246041

RH132318 (e-PCR)
- UniSTS:215601

RH131856 (e-PCR)
- UniSTS:215139

Slc16a1 (e-PCR), detects polymorphism
- UniSTS:461930

AI008262 (e-PCR)
- UniSTS:250506

D2Wox36 (e-PCR)
- UniSTS:517790

RH129106 (e-PCR)
- UniSTS:212414

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylic acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lactate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables lactate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lactate:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables monocarboxylic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monocarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables solute:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in behavioral response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lactate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lactate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monocarboxylic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monocarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane lactate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane lactate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane lactate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane lactate transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyruvate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to food	ISO Inferred from Sequence Orthology more info
involved_in succinate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in succinate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monocarboxylate transporter 1

Names: MCT 1; solute carrier 16 (monocarboxylic acid transporter), member 1; solute carrier family 16 (monocarboxylate transporter), member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012716.2 → NP_036848.1 monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_036848.1

Status: PROVISIONAL

Source sequence(s)

BC078877

UniProtKB/Swiss-Prot

P53987

UniProtKB/TrEMBL

A0A8I6AI36, A6K3P1

Related

ENSRNOP00000027234.3, ENSRNOT00000027234.7

Conserved Domains (1) summary

TIGR00892
Location:1 → 462

2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

194805556..194832966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101760.2 → XP_038957688.1 monocarboxylate transporter 1 isoform X1

UniProtKB/Swiss-Prot

P53987

UniProtKB/TrEMBL

A0A8I6AI36, A6K3P1

Conserved Domains (1) summary

TIGR00892
Location:1 → 462

2A0113; monocarboxylate transporter 1
XM_063281316.1 → XP_063137386.1 monocarboxylate transporter 1 isoform X1

UniProtKB/Swiss-Prot

P53987

UniProtKB/TrEMBL

A6K3P1

Related

ENSRNOP00000092404.1, ENSRNOT00000116493.2