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    AIM44 Aim44p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIM44
    Official Full Name
    Aim44p
    Primary source
    SGD:S000006079
    Locus tag
    YPL158C
    See related
    AllianceGenome:SGD:S000006079; FungiDB:YPL158C; VEuPathDB:YPL158C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GPS1
    Summary
    Involved in several processes, including cytokinetic process; protein localization to cell division site after cytokinesis; and regulation of protein localization to cell division site. Located in cleavage apparatus septin structure; nuclear inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIM44 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (252034..254310, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene leucine--tRNA ligase CDC60 Neighboring gene Pet20p Neighboring gene RNA methyltransferase Neighboring gene pheromone-regulated protein PRM4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in budding yeast. Wolken DM, et al. Mol Biol Cell, 2014 Mar. PMID 24451263, Free PMC Article
    2. Cellular localization of Sun4p and its interaction with proteins in the yeast birth scar. Kuznetsov E, et al. Cell Cycle, 2016 Jul 17. PMID 27229769, Free PMC Article
    3. Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Doolin MT, et al. Mol Microbiol, 2001 Apr. PMID 11309124
    4. The septin-associated kinase Gin4 recruits Gps1 to the site of cell division. Meitinger F, et al. Mol Biol Cell, 2017 Apr 1. PMID 28148650, Free PMC Article
    5. Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein. Miller KE, et al. Mol Biol Cell, 2017 Dec 15. PMID 29074565, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in Saccharomyces cerevisiae.
      Title: Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of protein location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell division site after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to cell division site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secondary cell septum biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in secondary cell septum biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular bud neck IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cellular bud neck septin collar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck split septin rings IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in nuclear inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aim44p
    NP_015167.1
    • Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      252034..254310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183972.1 → NP_015167.1  TPA: Aim44p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZW95, B3LKR9, C8ZIM0, D6W3L0, Q99299
      UniProtKB/TrEMBL
      N1NVU3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99299.1

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