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    Slc25a21 solute carrier family 25 member 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171151, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a21provided by RGD
    Official Full Name
    solute carrier family 25 member 21provided by RGD
    Primary source
    RGD:621444
    See related
    EnsemblRapid:ENSRNOG00000008931 AllianceGenome:RGD:621444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Odc1
    Summary
    Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 86.8), Kidney (RPKM 34.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a21 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (79938480..80437937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (74203439..74702902, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (77624384..78121339, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15, pseudogene 2 Neighboring gene NK2 homeobox 8 Neighboring gene paired box 9 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 2 Neighboring gene uncharacterized LOC108351240 Neighboring gene uncharacterized LOC134479389 Neighboring gene uncharacterized LOC120103539 Neighboring gene transfer RNA valine (anticodon AAC) 44 Neighboring gene U6 spliceosomal RNA Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 3 Neighboring gene mirror-image polydactyly 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location. Fiermonte G, et al. J Biol Chem, 2001 Mar 16. PMID 11083877
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105329

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-ketoglutarate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-ketoglutarate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial alpha-ketoglutarate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial alpha-ketoglutarate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial 2-oxodicarboxylate carrier
    Names
    oxodicarboxylate carrier
    solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
    solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133614.3 → NP_598298.1  mitochondrial 2-oxodicarboxylate carrier

      See identical proteins and their annotated locations for NP_598298.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q99JD3
      UniProtKB/TrEMBL
      A0A140TAF1, A6HBP1
      Related
      ENSRNOP00000084175.1, ENSRNOT00000119506.2
      Conserved Domains (2) summary
      PTZ00168
      Location:11 → 280
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:14 → 104
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      79938480..80437937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111745.2 → XP_038967673.1  mitochondrial 2-oxodicarboxylate carrier isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:14 → 104
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JD3.1 GenPept UniProtKB/Swiss-Prot:Q99JD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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