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    Sec23a Sec23 homolog A, COPII coat complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58817, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sec23aprovided by RGD
    Official Full Name
    Sec23 homolog A, COPII coat complex componentprovided by RGD
    Primary source
    RGD:1309103
    See related
    EnsemblRapid:ENSRNOG00000004657 AllianceGenome:RGD:1309103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading and protein localization to plasma membrane. Predicted to be located in bounding membrane of organelle; cytosol; and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 284.1), Liver (RPKM 242.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sec23a in Genome Data Viewer
    Location:
    6q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (82393699..82442594, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (76658793..76706125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (80059742..80107340, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene RAD9, HUS1, RAD1-interacting nuclear orphan protein 1-like Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 8 Neighboring gene high mobility group protein B1-like Neighboring gene gem (nuclear organelle) associated protein 2 Neighboring gene cytochrome P450, family 51, subfamily a, polypeptide 1, pseudogene 1 Neighboring gene U2 spliceosomal RNA like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic stellate cell activation through ER-Golgi transport. Tomoishi S, et al. Sci Rep, 2017 Aug 11. PMID 28801610, Free PMC Article
    2. Cloning and functional characterization of mammalian homologues of the COPII component Sec23. Paccaud JP, et al. Mol Biol Cell, 1996 Oct. PMID 8898360, Free PMC Article
    3. SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. Bruno J, et al. J Cell Biol, 2016 Jul 4. PMID 27354378, Free PMC Article
    4. TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion. Maeda M, et al. J Cell Biol, 2017 Jun 5. PMID 28442536, Free PMC Article
    5. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. Zhang J, et al. FEBS Lett, 2005 Jan 17. PMID 15642376

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sec23A expression is upregulated via CREB3L2 during hepatic stellate cells activation. Sec23A knockdown abrogated the activation.
      Title: CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic stellate cell activation through ER-Golgi transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ER to Golgi transport vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec23A
    Names
    Sec23 homolog A, coat complex II component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105732.3 → NP_001099202.1  protein transport protein Sec23A isoform 1

      See identical proteins and their annotated locations for NP_001099202.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JZM2, B5DFC3, F7F6X6
      Related
      ENSRNOP00000006369.4, ENSRNOT00000006369.8
      Conserved Domains (1) summary
      PLN00162
      Location:12 → 763
      PLN00162; transport protein sec23; Provisional

    2. NM_001434088.1 → NP_001421017.1  protein transport protein Sec23A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001434089.1 → NP_001421018.1  protein transport protein Sec23A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    4. NM_001434090.1 → NP_001421019.1  protein transport protein Sec23A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    5. NM_001434091.1 → NP_001421020.1  protein transport protein Sec23A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      82393699..82442594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262378.1 → XP_063118448.1  protein transport protein Sec23A isoform X1

      UniProtKB/TrEMBL
      B5DFC3, F7F6X6

    2. XM_039112796.2 → XP_038968724.1  protein transport protein Sec23A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZM2, B5DFC3, F7F6X6
      Conserved Domains (1) summary
      PLN00162
      Location:12 → 763
      PLN00162; transport protein sec23; Provisional

    3. XM_008764661.4 → XP_008762883.1  protein transport protein Sec23A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZM2, B5DFC3, F7F6X6
      Conserved Domains (1) summary
      PLN00162
      Location:12 → 763
      PLN00162; transport protein sec23; Provisional

    4. XM_063262377.1 → XP_063118447.1  protein transport protein Sec23A isoform X1

      UniProtKB/TrEMBL
      B5DFC3, F7F6X6

    5. XM_039112797.2 → XP_038968725.1  protein transport protein Sec23A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZM2
      Conserved Domains (1) summary
      PLN00162
      Location:1 → 637
      PLN00162; transport protein sec23; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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