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    Tymp thymidine phosphorylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315219, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tympprovided by RGD
    Official Full Name
    thymidine phosphorylaseprovided by RGD
    Primary source
    RGD:1305756
    See related
    EnsemblRapid:ENSRNOG00000032394 AllianceGenome:RGD:1305756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TP; Ecgf1
    Summary
    Predicted to enable protein homodimerization activity and thymidine phosphorylase activity. Predicted to be involved in several processes, including dTMP catabolic process; regulation of gastric motility; and regulation of myelination. Predicted to be located in mitochondrial inner membrane and myofibril. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 519.2), Thymus (RPKM 105.8) and 9 other tissues See more
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    Genomic context

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    See Tymp in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122318396..122323716, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120438768..120444088, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130342481..130347845, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene ciliary microtubule associated protein 1B Neighboring gene kelch domain containing 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prognostic value of thymidine phosphorylase expression for pancreatic cancer. Hong SP, et al. Hepatogastroenterology, 2009 Jul-Aug. PMID 19760965
    2. Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast. Engels K, et al. J Pathol, 1997 Aug. PMID 9306962
    3. The activity of thymidine phosphorylase correlates with tumor size and lymph nodes status in breast carcinoma. Kubiak R, et al. Z Naturforsch C J Biosci, 1999 Dec. PMID 10685502
    4. Significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor in carcinoma of the papilla of Vater. Zhao B, et al. Jpn J Cancer Res, 2000 Mar. PMID 10760693, Free PMC Article
    5. Angiogenesis and lymphangiogenesis in stage 1 germ cell tumours of the testis. Jones A, et al. BJU Int, 2000 Jul. PMID 10886088

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PyNpase levels in rat bladder tissue were significantly higher in the BBN-treatment groups than in those in the control group, only during the early carcinogenic stage
      Title: Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108801, MGC112734

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular copper ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gastric motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thymidine phosphorylase
    Names
    endothelial cell growth factor 1 (platelet-derived)
    tdRPase
    NP_001012122.1
    XP_006242271.1
    XP_008763952.1
    XP_038935237.1
    XP_038935238.1
    XP_038935239.1
    XP_038935241.1
    XP_063119723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012122.2 → NP_001012122.1  thymidine phosphorylase

      See identical proteins and their annotated locations for NP_001012122.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5FVR2
      UniProtKB/TrEMBL
      A6K7M1
      Conserved Domains (4) summary
      smart00941
      Location:381 → 455
      PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain
      TIGR02644
      Location:30 → 439
      Y_phosphoryl; pyrimidine-nucleoside phosphorylase
      pfam00591
      Location:103 → 333
      Glycos_transf_3; Glycosyl transferase family, a/b domain
      pfam02885
      Location:31 → 91
      Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122318396..122323716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079310.2 → XP_038935238.1  thymidine phosphorylase isoform X4

      Related
      ENSRNOP00000039935.4, ENSRNOT00000040541.6
      Conserved Domains (2) summary
      cd02968
      Location:592 → 733
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
      cl29556
      Location:30 → 380
      Glycos_transf_3; Glycosyl transferase family, a/b domain

    2. XM_006242209.5 → XP_006242271.1  thymidine phosphorylase isoform X3

      Conserved Domains (4) summary
      COG0547
      Location:28 → 343
      TrpD; Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]
      cd02968
      Location:593 → 734
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
      pfam00591
      Location:103 → 334
      Glycos_transf_3; Glycosyl transferase family, a/b domain
      pfam02885
      Location:31 → 91
      Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

    3. XM_039079309.2 → XP_038935237.1  thymidine phosphorylase isoform X2

      Conserved Domains (2) summary
      cd02968
      Location:594 → 735
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
      cl29556
      Location:30 → 382
      Glycos_transf_3; Glycosyl transferase family, a/b domain

    4. XM_008765730.4 → XP_008763952.1  thymidine phosphorylase isoform X1

      Conserved Domains (4) summary
      COG0547
      Location:28 → 345
      TrpD; Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]
      cd02968
      Location:595 → 736
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
      pfam00591
      Location:103 → 336
      Glycos_transf_3; Glycosyl transferase family, a/b domain
      pfam02885
      Location:31 → 91
      Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

    5. XM_039079311.2 → XP_038935239.1  thymidine phosphorylase isoform X5

      Conserved Domains (2) summary
      cd02968
      Location:341 → 482
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
      cl29556
      Location:2 → 129
      Glycos_transf_3; Glycosyl transferase family, a/b domain

    6. XM_039079313.2 → XP_038935241.1  thymidine phosphorylase isoform X7

      Conserved Domains (1) summary
      cl40719
      Location:30 → 442
      PRK06078; pyrimidine-nucleoside phosphorylase; Reviewed

    7. XM_063263653.1 → XP_063119723.1  thymidine phosphorylase isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVR2.1 GenPept UniProtKB/Swiss-Prot:Q5FVR2

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