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    Slc38a4 solute carrier family 38, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc38a4provided by RGD
    Official Full Name
    solute carrier family 38, member 4provided by RGD
    Primary source
    RGD:621836
    See related
    EnsemblRapid:ENSRNOG00000006653 AllianceGenome:RGD:621836
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ata3
    Summary
    Enables neutral L-amino acid:sodium symporter activity. Involved in neutral amino acid transport. Predicted to be located in microvillus membrane. Predicted to be active in plasma membrane. Orthologous to human SLC38A4 (solute carrier family 38 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1589.5) and Muscle (RPKM 275.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc38a4 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (130022039..130082169, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (128142866..128203000, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (138459576..138512952, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene proline-rich basic protein 1, pseudogene 2 Neighboring gene uncharacterized LOC108351545 Neighboring gene uncharacterized LOC120093722 Neighboring gene uncharacterized LOC108351546 Neighboring gene uncharacterized LOC120093723 Neighboring gene uncharacterized LOC120093724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Sugawara M, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11118514
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alanine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neutral L-amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-alanine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-alanine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-alanine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid transporter 4
    Names
    Na(+)-coupled neutral amino acid transporter 4
    amino acid transport system A3
    amino acid transporter A3
    system A amino acid transporter 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130748.1 → NP_570104.1  sodium-coupled neutral amino acid transporter 4

      See identical proteins and their annotated locations for NP_570104.1

      Status: PROVISIONAL

      Source sequence(s)
      AF295535
      UniProtKB/Swiss-Prot
      Q9EQ25
      UniProtKB/TrEMBL
      A6KC31
      Related
      ENSRNOP00000009187.2, ENSRNOT00000009187.7
      Conserved Domains (1) summary
      cl00456
      Location:73 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      130022039..130082169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078322.1 → XP_038934250.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQ25
      UniProtKB/TrEMBL
      A6KC31
      Conserved Domains (1) summary
      cl00456
      Location:73 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_008765663.3 → XP_008763885.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_008763885.1

      UniProtKB/Swiss-Prot
      Q9EQ25
      UniProtKB/TrEMBL
      A6KC31
      Conserved Domains (1) summary
      cl00456
      Location:73 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQ25.1 GenPept UniProtKB/Swiss-Prot:Q9EQ25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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