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    Fam169a family with sequence similarity 169, member A [ Mus musculus (house mouse) ]

    Gene ID: 320557, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam169aprovided by MGI
    Official Full Name
    family with sequence similarity 169, member Aprovided by MGI
    Primary source
    MGI:MGI:2444268
    See related
    Ensembl:ENSMUSG00000041817 AllianceGenome:MGI:2444268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLAP75; B230112C05Rik
    Summary
    Predicted to be located in nuclear inner membrane. Is expressed in cerebellum external granule cell layer; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human FAM169A (family with sequence similarity 169 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 6.8), frontal lobe adult (RPKM 5.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam169a in Genome Data Viewer
    Location:
    13 D1; 13 50.66 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97203795..97266801)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97067287..97130293)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41027 Neighboring gene RIKEN cDNA 1700029F12 gene Neighboring gene predicted gene, 41028 Neighboring gene STARR-seq mESC enhancer starr_35359 Neighboring gene STARR-seq mESC enhancer starr_35363 Neighboring gene proteolipid protein 2, retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene ectodermal-neural cortex 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3. Sánchez-Bellver L, et al. Int J Mol Sci, 2022 Oct 19. PMID 36293380, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    soluble lamin-associated protein of 75 kDa
    Names
    protein FAM169A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100458.1 → NP_001093928.1  soluble lamin-associated protein of 75 kDa

      See identical proteins and their annotated locations for NP_001093928.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK173051, AW123559, BG261627
      Consensus CDS
      CCDS49337.1
      UniProtKB/Swiss-Prot
      E9Q0D7, Q5XG69, Q69ZW7
      Related
      ENSMUSP00000043738.7, ENSMUST00000042517.8
      Conserved Domains (1) summary
      COG3144
      Location:337 → 587
      FliK; Flagellar hook-length control protein FliK [Cell motility]

    2. NM_001146045.1 → NP_001139517.1  soluble lamin-associated protein of 75 kDa

      See identical proteins and their annotated locations for NP_001139517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK173051, AW123559, BC084589, CX734408
      Consensus CDS
      CCDS49337.1
      UniProtKB/Swiss-Prot
      E9Q0D7, Q5XG69, Q69ZW7
      Related
      ENSMUSP00000126209.2, ENSMUST00000169863.9
      Conserved Domains (1) summary
      COG3144
      Location:337 → 587
      FliK; Flagellar hook-length control protein FliK [Cell motility]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97203795..97266801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158070.1 → XP_036013963.1  soluble lamin-associated protein of 75 kDa isoform X3

    2. XM_030247298.2 → XP_030103158.1  soluble lamin-associated protein of 75 kDa isoform X3

    3. XM_030247299.2 → XP_030103159.1  soluble lamin-associated protein of 75 kDa isoform X4

    4. XM_030247297.2 → XP_030103157.1  soluble lamin-associated protein of 75 kDa isoform X2

    5. XM_006517686.4 → XP_006517749.1  soluble lamin-associated protein of 75 kDa isoform X1

      See identical proteins and their annotated locations for XP_006517749.1

      UniProtKB/Swiss-Prot
      E9Q0D7, Q5XG69, Q69ZW7
      Conserved Domains (1) summary
      COG3144
      Location:337 → 587
      FliK; Flagellar hook-length control protein FliK [Cell motility]

    6. XM_011244669.3 → XP_011242971.1  soluble lamin-associated protein of 75 kDa isoform X1

      See identical proteins and their annotated locations for XP_011242971.1

      UniProtKB/Swiss-Prot
      E9Q0D7, Q5XG69, Q69ZW7
      Conserved Domains (1) summary
      COG3144
      Location:337 → 587
      FliK; Flagellar hook-length control protein FliK [Cell motility]

    7. XM_036158069.1 → XP_036013962.1  soluble lamin-associated protein of 75 kDa isoform X1

      UniProtKB/Swiss-Prot
      E9Q0D7, Q5XG69, Q69ZW7
      Conserved Domains (1) summary
      COG3144
      Location:337 → 587
      FliK; Flagellar hook-length control protein FliK [Cell motility]

    8. XM_036158071.1 → XP_036013964.1  soluble lamin-associated protein of 75 kDa isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XG69.3 GenPept UniProtKB/Swiss-Prot:Q5XG69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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