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    Plekhd1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 [ Mus musculus (house mouse) ]

    Gene ID: 217682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekhd1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family D (with coiled-coil domains) member 1provided by MGI
    Primary source
    MGI:MGI:3036228
    See related
    Ensembl:ENSMUSG00000066438 AllianceGenome:MGI:3036228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3830431G21Rik
    Summary
    Is expressed in dorsal root ganglion; midbrain mantle layer; rest of cerebellum mantle layer; and trigeminal ganglion. Orthologous to human PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 11.3), placenta adult (RPKM 7.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekhd1 in Genome Data Viewer
    Location:
    12 C3; 12 36.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80739375..80770990)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80692601..80724216)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4032 Neighboring gene solute carrier family 39 (zinc transporter), member 9 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1, opposite strand Neighboring gene predicted gene, 51986 Neighboring gene STARR-seq mESC enhancer starr_32646 Neighboring gene coiled-coil domain containing 177 Neighboring gene STARR-seq mESC enhancer starr_32647 Neighboring gene STARR-seq mESC enhancer starr_32648 Neighboring gene sushi domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_32649 Neighboring gene STARR-positive B cell enhancer ABC_E5337 Neighboring gene STARR-seq mESC enhancer starr_32653

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family D member 1
    Names
    PH domain-containing family D member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177503.1 → NP_001170974.1  pleckstrin homology domain-containing family D member 1

      See identical proteins and their annotated locations for NP_001170974.1

      Status: VALIDATED

      Source sequence(s)
      AC134537, AI747346, AK028383, CF353072
      Consensus CDS
      CCDS49100.1
      UniProtKB/Swiss-Prot
      B2RPU2
      Related
      ENSMUSP00000119711.2, ENSMUST00000140770.2
      Conserved Domains (3) summary
      cd13281
      Location:18 → 156
      PH_PLEKHD1; Pleckstrin homology (PH) domain containing, family D (with coiled-coil domains) member 1 PH domain
      pfam00169
      Location:29 → 134
      PH; PH domain
      pfam09798
      Location:168 → 285
      LCD1; DNA damage checkpoint protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      80739375..80770990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515683.5 → XP_006515746.1  pleckstrin homology domain-containing family D member 1 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:146 → 392
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13281
      Location:18 → 156
      PH_PLEKHD1; Pleckstrin homology (PH) domain containing, family D (with coiled-coil domains) member 1 PH domain

    2. XM_036157310.1 → XP_036013203.1  pleckstrin homology domain-containing family D member 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:117 → 363
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17171
      Location:22 → 127
      PH-like; Pleckstrin homology-like domain

    3. XM_011244059.1 → XP_011242361.1  pleckstrin homology domain-containing family D member 1 isoform X1

      See identical proteins and their annotated locations for XP_011242361.1

      Conserved Domains (2) summary
      COG1196
      Location:117 → 363
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17171
      Location:22 → 127
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RPU2.1 GenPept UniProtKB/Swiss-Prot:B2RPU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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