Unc5b unc-5 netrin receptor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc5bprovided by MGI
Official Full Name: unc-5 netrin receptor Bprovided by MGI
Primary source: MGI:MGI:894703
See related: Ensembl:ENSMUSG00000020099 AllianceGenome:MGI:894703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik
Summary: Predicted to enable netrin receptor activity. Acts upstream of or within anterior/posterior axon guidance. Predicted to be located in membrane raft. Is expressed in several structures, including brain; forelimb; ganglia; limb bud; and sensory organ. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in small intestine adult (RPKM 21.1), colon adult (RPKM 20.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 31.52 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (60598373..60667360, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (60762594..60831581, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching.
Title: Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching.
Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
Title: Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
GPC3-Unc5 receptor complex structure and role in cell migration.
Title: GPC3-Unc5 receptor complex structure and role in cell migration.
Endothelial Unc5B controls blood-brain barrier integrity.
Title: Endothelial Unc5B controls blood-brain barrier integrity.
Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
Title: Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.
Title: Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.
Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
Title: Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signaling.
Title: Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.
Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.
Title: Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10).
fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
Title: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Unc5b (e-PCR), detects polymorphism
- UniSTS:498455

RH125085 (e-PCR)
- UniSTS:161907

Unc5h2 (e-PCR), detects polymorphism
- UniSTS:259457

D10Bwg0792e (e-PCR), detects polymorphism
- UniSTS:141494

Unc5b (e-PCR), detects polymorphism
- UniSTS:498415

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables netrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables netrin receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info	PubMed
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: netrin receptor UNC5B

Names: protein unc-5 homolog 2; protein unc-5 homolog B; unc5 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359273.1 → NP_001346202.1 netrin receptor UNC5B isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK018177, AK147603, AW488068, BC048162

Consensus CDS

CCDS88011.1

UniProtKB/TrEMBL

Q3TYW6

Related

ENSMUSP00000151251.2, ENSMUST00000218637.2

Conserved Domains (5) summary

smart00218
Location:530 → 633

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08802
Location:847 → 930

Death_UNC5B; Death domain found in Uncoordinated-5B

smart00209
Location:249 → 300

TSP1; Thrombospondin type 1 repeats

pfam17217
Location:680 → 819

UPA; UPA domain

cl11960
Location:157 → 243

Ig; Immunoglobulin domain
NM_029770.3 → NP_084046.2 netrin receptor UNC5B isoform 1 precursor

See identical proteins and their annotated locations for NP_084046.2

Status: VALIDATED

Source sequence(s)

AK018177, AK147603, AK158284, AW488068, BC048162

Consensus CDS

CCDS23872.1

UniProtKB/Swiss-Prot

Q3U4F2, Q6PFH0, Q80Y85, Q8K1S3, Q9D398

UniProtKB/TrEMBL

Q3TYW6

Related

ENSMUSP00000077080.6, ENSMUST00000077925.7

Conserved Domains (5) summary

smart00218
Location:541 → 644

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08802
Location:858 → 941

Death_UNC5B; Death domain found in Uncoordinated-5B

smart00209
Location:249 → 300

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:155 → 243

I-set; Immunoglobulin I-set domain

cl11960
Location:157 → 243

Ig; Immunoglobulin domain