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    Nccrp1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) [ Mus musculus (house mouse) ]

    Gene ID: 233038, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nccrp1provided by MGI
    Official Full Name
    non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)provided by MGI
    Primary source
    MGI:MGI:2685009
    See related
    Ensembl:ENSMUSG00000047586 AllianceGenome:MGI:2685009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm163; NCCRP-1; 1190020J12Rik
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in glycoprotein catabolic process; positive regulation of cell population proliferation; and proteasomal protein catabolic process. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human NCCRP1 (NCCRP1, F-box associated domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 27.2), stomach adult (RPKM 14.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nccrp1 in Genome Data Viewer
    Location:
    7 A3; 7 16.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28243017..28247168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28543592..28547748, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene syncollin Neighboring gene predicted gene, 38977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342572-29342755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342797-29343021 Neighboring gene microRNA 7049 Neighboring gene p21 (RAC1) activated kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 50
    Names
    NCC receptor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081115.2 → NP_001074584.2  F-box only protein 50

      Status: VALIDATED

      Source sequence(s)
      AC136456
      Consensus CDS
      CCDS39862.2
      UniProtKB/Swiss-Prot
      G3X9C2, Q8BT24
      UniProtKB/TrEMBL
      A0A0A0MQ97
      Related
      ENSMUSP00000159104.2, ENSMUST00000239002.2
      Conserved Domains (1) summary
      pfam04300
      Location:90 → 260
      FBA; F-box associated region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28243017..28247168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242451.2 → XP_030098311.1  F-box only protein 50 isoform X1

      UniProtKB/Swiss-Prot
      G3X9C2, Q8BT24
      UniProtKB/TrEMBL
      A0A0A0MQ97
      Conserved Domains (1) summary
      pfam04300
      Location:90 → 260
      FBA; F-box associated region

    2. XM_030242452.1 → XP_030098312.1  F-box only protein 50 isoform X2

      Conserved Domains (1) summary
      pfam04300
      Location:7 → 131
      FBA; F-box associated region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3X9C2.2 GenPept UniProtKB/Swiss-Prot:G3X9C2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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