Hyal2 hyaluronoglucosaminidase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hyal2provided by MGI
Official Full Name: hyaluronoglucosaminidase 2provided by MGI
Primary source: MGI:MGI:1196334
See related: Ensembl:ENSMUSG00000010047 AllianceGenome:MGI:1196334
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables several functions, including hyalurononglucosaminidase activity; transforming growth factor beta binding activity; and virus receptor activity. Contributes to transcription coactivator activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; hyaluronan catabolic process; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; multicellular organismal-level iron ion homeostasis; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface; membrane raft; and plasma membrane. Part of RNA polymerase II transcription regulator complex. Colocalizes with external side of plasma membrane. Is expressed in several structures, including alimentary system; heart; lateral plate mesoderm; respiratory system; and submandibular gland primordium. Orthologous to human HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 54.9), duodenum adult (RPKM 43.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 58.12 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107445096..107449975)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107567873..107572778)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells.
Title: Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells.
Mice deficient in HYAL2 are more susceptible to an acute model of colitis, and this increased susceptibility is abrogated by transfusion of HYAL2-competent platelets.
Title: Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis.
Knockdown of Hyal2 in articular cartilage induced osteoarthritis development and progression possibly mediated by an imbalance of hyaluronan metabolism.
Title: Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.
Hyal2(-/-) mice have increased hyaluronan, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells leading to congenital heart defects and heart failure.
Title: Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.
It was concluded that: HYAL1 and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs.
Title: Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover.
Hyal2-/- mice present craniofacial abnormalities, including submucosal cleft palate and incompletely penetrant cor triatriatum sinister with hearing loss.
Title: Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Title: Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis.
Removal of Hyal2 activity resulted in increased levels of hyaluronan creating a risk for cor triatriatum sinister.
Title: Hyaluronidase 2 deficiency is a molecular cause of cor triatriatum sinister in mice.
hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.
Title: Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions
Title: Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

AW555733 (e-PCR)
- UniSTS:179979

RH136576 (e-PCR)
- UniSTS:210556

Hyal2 (e-PCR), detects polymorphism
- UniSTS:532617

RH136104 (e-PCR)
- UniSTS:210099

Hyal2 (e-PCR), detects polymorphism
- UniSTS:526012

Hyal2 (e-PCR), detects polymorphism
- UniSTS:526013

UniSTS:236246 (e-PCR)
- UniSTS:236246

Hyal2 (e-PCR), detects polymorphism
- UniSTS:256471

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hyaluronoglucuronidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronoglucuronidase activity	ISO Inferred from Sequence Orthology more info
enables hyaluronoglucuronidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hyalurononglucosaminidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hyalurononglucosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables receptor signaling protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
contributes_to transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in fusion of virus membrane with host plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in fusion of virus membrane with host plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosaminoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycosaminoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyaluronan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of urine volume	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal water absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hyaluronidase-2

Names: hyal-2

NP_001396600.1

EC 3.2.1.35

NP_001396601.1

EC 3.2.1.35

NP_034619.2

EC 3.2.1.35

XP_006511706.1

EC 3.2.1.35

XP_036010506.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.