Aqp1 aquaporin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aqp1provided by MGI
Official Full Name: aquaporin 1provided by MGI
Primary source: MGI:MGI:103201
See related: Ensembl:ENSMUSG00000004655 AllianceGenome:MGI:103201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CHIP28
Summary: Enables ephrin receptor binding activity; potassium ion transmembrane transporter activity; and water transmembrane transporter activity. Involved in several processes, including defense response to Gram-negative bacterium; lateral ventricle development; and metanephros development. Acts upstream of or within several processes, including corticotropin secretion; glomerular filtration; and renal water absorption. Located in several cellular components, including basolateral plasma membrane; brush border; and extracellular exosome. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in kidney adult (RPKM 483.5), lung adult (RPKM 456.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (55313284..55325540)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (55336299..55348555)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of P53 expression.
Title: Aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of P53 expression.
Aquaporin 1 Facilitates Ferroptosis, M1 Polarization, Mitochondrial Dysfunction, and Autophagy Damage on Lipopolysaccharide-Induced Macrophage Through Down-Regulation of P53 Signaling Pathway.
Title: Aquaporin 1 Facilitates Ferroptosis, M1 Polarization, Mitochondrial Dysfunction, and Autophagy Damage on Lipopolysaccharide-Induced Macrophage Through Down-Regulation of P53 Signaling Pathway.
AQP1 in the Gastrointestinal Tract of Mice: Expression Pattern and Impact of AQP1 Knockout on Colonic Function.
Title: AQP1 in the Gastrointestinal Tract of Mice: Expression Pattern and Impact of AQP1 Knockout on Colonic Function.
Changes in aquaporins expression due to acute water restriction in naturally aging mice.
Title: Changes in aquaporins expression due to acute water restriction in naturally aging mice.
Aquaporin-1 inhibition exacerbates ischemia-reperfusion-induced lung injury in mouse.
Title: Aquaporin-1 inhibition exacerbates ischemia-reperfusion-induced lung injury in mouse.
Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume.
Title: Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume.
Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development.
Title: Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development.
Vasopressin V1a Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury.
Title: Vasopressin V(1a) Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury.
Co-expression of glycosylated aquaporin-1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis-prone mice.
Title: Co-expression of glycosylated aquaporin-1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis-prone mice.
Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth.
Title: Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth.

Submit: New GeneRIF Correction See all GeneRIFs (111)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

General gene information

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Markers

Aqp1 (e-PCR), detects polymorphism
- UniSTS:186490

Aqp1 (e-PCR), detects polymorphism
- UniSTS:209562

NoName (e-PCR)
- UniSTS:548511

L02914 (e-PCR)
- UniSTS:179376

Aqp1 (e-PCR), detects polymorphism
- UniSTS:530941

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	ISO Inferred from Sequence Orthology more info
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbon dioxide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbon dioxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables glycerol transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glycerol transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrogen peroxide channel activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables nitric oxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nitric oxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	TAS Traceable Author Statement more info	PubMed
enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbon dioxide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbon dioxide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbon dioxide transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mercury ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nitric oxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to salt stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to salt stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebrospinal fluid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within corticotropin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of actin cytoskeleton polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in hydrogen peroxide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lateral ventricle development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lipid digestion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric descending thin limb development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric glomerulus vasculature development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric proximal convoluted tubule segment 2 development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric proximal straight tubule development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide transport	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of saliva secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within renal water absorption	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within renal water absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal water transport	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion by cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transepithelial water transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial water transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within water transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within water transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within water transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in water transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
part_of ankyrin-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dense core granule membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aquaporin-1

Names: AQP-1; DER2; aquaporin-CHIP; delayed early response protein 2; growth factor-induced delayed early response protein; water channel protein for red blood cells and kidney proximal tubule

NP_031498.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.