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    Kctd12b potassium channel tetramerisation domain containing 12b [ Mus musculus (house mouse) ]

    Gene ID: 207474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kctd12bprovided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 12bprovided by MGI
    Primary source
    MGI:MGI:2444667
    See related
    Ensembl:ENSMUSG00000041633 AllianceGenome:MGI:2444667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530071H11Rik; B430319H24Rik
    Summary
    Enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Part of receptor complex. Is active in GABA-ergic synapse and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 4.1), subcutaneous fat pad adult (RPKM 3.7) and 23 other tissues See more
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    Genomic context

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    See Kctd12b in Genome Data Viewer
    Location:
    X F3; X 71.79 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (152468150..152479382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (153685154..153696386, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39543 Neighboring gene predicted gene, 25793 Neighboring gene predicted gene 8534 Neighboring gene predicted gene 45022 Neighboring gene negative regulator of P-body association

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. Metz M, et al. J Comp Neurol, 2011 Jun 1. PMID 21452234
    2. GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. Bhandari P, et al. Elife, 2021 Apr 29. PMID 33913808, Free PMC Article
    3. Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, et al. Nature, 2010 May 13. PMID 20400944
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
      Title: GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
    2. Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
      Title: Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium channel tetramerisation domain containing 12b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175429.4 → NP_780638.1  potassium channel tetramerisation domain containing 12b

      See identical proteins and their annotated locations for NP_780638.1

      Status: VALIDATED

      Source sequence(s)
      AL831725
      Consensus CDS
      CCDS30484.1
      UniProtKB/TrEMBL
      Q8C7J6
      Related
      ENSMUSP00000037539.9, ENSMUST00000039424.14
      Conserved Domains (1) summary
      cd18367
      Location:19 → 118
      BTB_POZ_KCTD8-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      152468150..152479382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528778.2 → XP_006528841.1  potassium channel tetramerisation domain containing 12b isoform X1

      See identical proteins and their annotated locations for XP_006528841.1

      UniProtKB/TrEMBL
      Q8C7J6
      Related
      ENSMUSP00000108191.2, ENSMUST00000112572.3
      Conserved Domains (1) summary
      cd18367
      Location:19 → 118
      BTB_POZ_KCTD8-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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