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    Naprt nicotinate phosphoribosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 223646, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Naprtprovided by MGI
    Official Full Name
    nicotinate phosphoribosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2442664
    See related
    Ensembl:ENSMUSG00000022574 AllianceGenome:MGI:2442664
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naprt1; 9130210N20Rik
    Summary
    Predicted to enable nicotinate phosphoribosyltransferase activity. Predicted to be involved in NAD salvage and response to oxidative stress. Predicted to be active in cytosol. Is expressed in alimentary system and liver. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 179.7), small intestine adult (RPKM 113.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naprt in Genome Data Viewer
    Location:
    15 D3; 15 35.05 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75762812..75766330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75890963..75894481, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin D Neighboring gene STARR-seq mESC enhancer starr_39025 Neighboring gene maestro heat-like repeat family member 6 Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nomura M, et al. Nat Commun, 2023 Dec 13. PMID 38092728, Free PMC Article
    2. Trigonelline is an NAD(+) precursor that improves muscle function during ageing and is reduced in human sarcopenia. Membrez M, et al. Nat Metab, 2024 Mar. PMID 38504132, Free PMC Article
    3. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. Hara N, et al. J Biol Chem, 2007 Aug 24. PMID 17604275
    4. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, et al. Cell Chem Biol, 2017 May 18. PMID 28416276
    5. BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities. Yaku K, et al. Nat Commun, 2021 Nov 19. PMID 34799586, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases
      Title: Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.
    2. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD
      Title: Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate phosphoribosyltransferase
    Names
    NAPRTase
    nicotinate phosphoribosyltransferase domain containing 1
    nicotinate phosphoribosyltransferase domain-containing protein 1
    NP_766195.2
    XP_030104341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172607.3 → NP_766195.2  nicotinate phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_766195.2

      Status: PROVISIONAL

      Source sequence(s)
      AK033661
      Consensus CDS
      CCDS27552.1
      UniProtKB/Swiss-Prot
      Q8C7W2, Q8CC86
      Related
      ENSMUSP00000023237.7, ENSMUST00000023237.8
      Conserved Domains (2) summary
      PLN02885
      Location:13 → 525
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:15 → 398
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75762812..75766330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248481.1 → XP_030104341.1  nicotinate phosphoribosyltransferase isoform X1

      Conserved Domains (1) summary
      PLN02885
      Location:2 → 358
      PLN02885; nicotinate phosphoribosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CC86.1 GenPept UniProtKB/Swiss-Prot:Q8CC86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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