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Links from GEO Profiles

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    Cldn3 claudin 3 [ Mus musculus (house mouse) ]

    Gene ID: 12739, updated on 28-Jan-2025

    Summary

    Official Symbol
    Cldn3provided by MGI
    Official Full Name
    claudin 3provided by MGI
    Primary source
    MGI:MGI:1329044
    See related
    Ensembl:ENSMUSG00000070473 AllianceGenome:MGI:1329044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mRVP1; Cpetr2
    Summary
    This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology. [provided by RefSeq, Aug 2012]
    Orthologs
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    Genomic context

    See Cldn3 in Genome Data Viewer
    Location:
    5 G2; 5 74.93 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135015068..135016330)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134986214..134987476)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9030607J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1310 Neighboring gene STARR-seq mESC enhancer starr_14556 Neighboring gene methyltransferase like 27 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135417798-135418057 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135427401-135427609 Neighboring gene claudin 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135442157-135442340 Neighboring gene STARR-seq mESC enhancer starr_14561 Neighboring gene Williams Beuren syndrome chromosome region 25 (human) Neighboring gene predicted gene, 57747 Neighboring gene ribosomal protein S29, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables protein binding PubMed 
    enables structural molecule activity  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in bicellular tight junction assembly  
    involved_in bicellular tight junction assembly  
    involved_in bicellular tight junction assembly  
    involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules PubMed 
    involved_in cell adhesion  
    involved_in cell junction maintenance PubMed 
    involved_in epithelial cell morphogenesis PubMed 
    involved_in establishment of endothelial blood-brain barrier PubMed 
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of wound healing  
    involved_in negative regulation of wound healing  
    involved_in positive regulation of bicellular tight junction assembly  
    involved_in positive regulation of bicellular tight junction assembly  
    involved_in positive regulation of cell junction assembly  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of metallopeptidase activity  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of wound healing  
    involved_in positive regulation of wound healing  
    involved_in regulation of cell morphogenesis  
    involved_in regulation of cell morphogenesis  
    involved_in regulation of membrane permeability  
    involved_in regulation of membrane permeability  
    involved_in regulation of transepithelial transport  
    involved_in regulation of transepithelial transport  
    involved_in response to Gram-positive bacterium  
    involved_in response to ethanol  
    involved_in response to hypoxia  
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in apical junction complex  
    located_in apicolateral plasma membrane PubMed 
    is_active_in bicellular tight junction  
    located_in bicellular tight junction PubMed 
    located_in bicellular tight junction  
    located_in cell-cell junction PubMed 
    located_in cell-cell junction  
    located_in lateral plasma membrane PubMed 
    located_in lateral plasma membrane  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in tight junction PubMed 
    located_in tight junction  

    General protein information

    Preferred Names
    claudin-3
    Names
    CPE-R 2
    CPE-receptor 2
    clostridium perfringens enterotoxin receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009902.4NP_034032.1  claudin-3

      See identical proteins and their annotated locations for NP_034032.1

      Status: VALIDATED

      Source sequence(s)
      AK002672, AV041302
      Consensus CDS
      CCDS19729.1
      UniProtKB/Swiss-Prot
      Q91X40, Q9Z0G9
      UniProtKB/TrEMBL
      Q3TMQ3, Q545A5
      Related
      ENSMUSP00000091799.3, ENSMUST00000094245.4
      Conserved Domains (1) summary
      cl21598
      Location:3167
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135015068..135016330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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