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    Sugp2 SURP and G patch domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 234373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sugp2provided by MGI
    Official Full Name
    SURP and G patch domain containing 2provided by MGI
    Primary source
    MGI:MGI:2678085
    See related
    Ensembl:ENSMUSG00000036054 AllianceGenome:MGI:2678085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfrs14; Srsf14; mKIAA0365
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nuclear body. Predicted to be active in nucleoplasm. Is expressed in cerebral cortex; craniocervical region bone; and rib. Orthologous to human SUGP2 (SURP and G-patch domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.9), whole brain E14.5 (RPKM 19.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sugp2 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70686838..70715755)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70234188..70263105)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10504 Neighboring gene transmembrane protein 161A Neighboring gene solute carrier family 25, member 42 Neighboring gene STARR-positive B cell enhancer ABC_E1103 Neighboring gene armadillo repeat containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene DEAD box helicase 49

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
    2. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Mozhui K, et al. Behav Genet, 2007 Jan. PMID 17131200
    3. Splicing factor TRA2B is required for neural progenitor survival. Roberts JM, et al. J Comp Neurol, 2014 Feb 1. PMID 23818142, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66544

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SURP and G-patch domain-containing protein 2
    Names
    arginine/serine-rich-splicing factor 14
    putative splicing factor, arginine/serine-rich 14
    serine/arginine-rich splicing factor 14
    splicing factor, arginine/serine-rich 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168290.2 → NP_001161762.1  SURP and G-patch domain-containing protein 2

      See identical proteins and their annotated locations for NP_001161762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC124327, AF518875, AK042293, BE981284
      Consensus CDS
      CCDS22362.1
      UniProtKB/Swiss-Prot
      Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
      Related
      ENSMUSP00000128029.2, ENSMUST00000164403.8
      Conserved Domains (3) summary
      pfam01585
      Location:997 → 1040
      G-patch; G-patch domain
      pfam01805
      Location:769 → 819
      Surp; Surp module
      cl02715
      Location:571 → 619
      Surp; Surp module

    2. NM_172755.4 → NP_766343.3  SURP and G-patch domain-containing protein 2

      See identical proteins and their annotated locations for NP_766343.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC124327, AF518875, AK042293
      Consensus CDS
      CCDS22362.1
      UniProtKB/Swiss-Prot
      Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
      Related
      ENSMUSP00000091167.5, ENSMUST00000093458.11
      Conserved Domains (3) summary
      pfam01585
      Location:997 → 1040
      G-patch; G-patch domain
      pfam01805
      Location:769 → 819
      Surp; Surp module
      cl02715
      Location:571 → 619
      Surp; Surp module

    RNA

    1. NR_165051.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124327

    2. NR_165052.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124327

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70686838..70715755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153946.1 → XP_036009839.1  SURP and G-patch domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
      Conserved Domains (3) summary
      pfam01585
      Location:997 → 1040
      G-patch; G-patch domain
      pfam01805
      Location:769 → 819
      Surp; Surp module
      cl02715
      Location:571 → 619
      Surp; Surp module

    2. XM_036153947.1 → XP_036009840.1  SURP and G-patch domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
      Conserved Domains (3) summary
      pfam01585
      Location:997 → 1040
      G-patch; G-patch domain
      pfam01805
      Location:769 → 819
      Surp; Surp module
      cl02715
      Location:571 → 619
      Surp; Surp module

    RNA

    1. XR_004934810.1 RNA Sequence

    2. XR_004934811.1 RNA Sequence

    3. XR_004934812.1 RNA Sequence

    4. XR_004934815.1 RNA Sequence

    5. XR_004934813.1 RNA Sequence

    6. XR_004934814.1 RNA Sequence

    7. XR_004934807.1 RNA Sequence

    8. XR_004934808.1 RNA Sequence

    9. XR_004934809.1 RNA Sequence

    10. XR_004934816.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH09.2 GenPept UniProtKB/Swiss-Prot:Q8CH09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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