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    SLI15 Sli15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLI15
    Official Full Name
    Sli15p
    Primary source
    SGD:S000000360
    Locus tag
    YBR156C
    See related
    AllianceGenome:SGD:S000000360; FungiDB:YBR156C; VEuPathDB:YBR156C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activator activity. Involved in chromosome segregation; regulation of cytokinesis; and septin cytoskeleton organization. Located in kinetochore microtubule and spindle midzone. Part of chromosome passenger complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLI15 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (551104..553200, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase core subunit RPB5 Neighboring gene HSP70/90 family co-chaperone CNS1 Neighboring gene Ics2p Neighboring gene Amn1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An engineered minimal chromosomal passenger complex reveals a role for INCENP/Sli15 spindle association in chromosome biorientation. Fink S, et al. J Cell Biol, 2017 Apr 3. PMID 28314741, Free PMC Article
    2. Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC-spindle interaction to ensure proper microtubule dynamics. Nakajima Y, et al. J Cell Biol, 2011 Jul 11. PMID 21727193, Free PMC Article
    3. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Tanaka TU, et al. Cell, 2002 Feb 8. PMID 11853667
    4. Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset. Mirchenko L, et al. Curr Biol, 2010 Aug 10. PMID 20619650, Free PMC Article
    5. A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Sandall S, et al. Cell, 2006 Dec 15. PMID 17174893, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ipl1-dependent phosphorylation of Sli15 therefore inhibits its association with microtubules both in vivo and in vitro and may negatively regulate the tension checkpoint mechanism.
      Title: Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.
    2. phosphorylation of INCENP/Sli15 is required for activation of the kinase Aurora B/Ipl1 and can occur in trans.
      Title: Phosphorylation regulates kinase and microtubule binding activities of the budding yeast chromosomal passenger complex in vitro.
    3. an engineered truncation of the Sli15 subunit of budding yeast chromosomal passenger complex that eliminates association with the inner centromere nevertheless supports proper chromosome segregation during both mitosis and meiosis
      Title: Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
    4. Cdk1 and Ipl1/Aurora cooperatively modulate microtubule dynamics and that Ipl1/Aurora-dependent phosphorylation of Sli15 controls spindle function by excluding the CPC from spindle regions engaged in microtubule polymerization
      Title: Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC-spindle interaction to ensure proper microtubule dynamics.
    5. dephosphorylation by Cdc14 inactivates the mitotic checkpoint
      Title: Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset.
    6. Findings reveal a new role for the central kinetochore in promoting Sli15 function, and suggest functional Ame1 is required for the correction of defective attachments by promoting the localization of Sli15/INCENP at kinetochores.
      Title: The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments.
    7. Data show that Utp7 plays essential roles in ribosome biogenesis, chromosome segregation, and cell cycle control, and that Utp7 associates with and regulates the localization of Sli15 and Cdc14.
      Title: Regulation of Sli15/INCENP, kinetochore, and Cdc14 phosphatase functions by the ribosome biogenesis protein Utp7.
    8. The interaction between Bir1p and Sli15p is specifically involved in regulating septin dynamics during anaphase.
      Title: A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase.
    9. Using an in vitro approach based on the sequence-specific budding yeast centromere, a complex of the chromosomal passenger proteins Bir1 and Sli15 (Survivin and INCENP) that links centromeres to microtubules was identified.
      Title: A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chromosome passenger complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sli15p
    NP_009714.3
    • Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      551104..553200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178504.3 → NP_009714.3  TPA: Sli15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009714.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQF1, P38283
      UniProtKB/TrEMBL
      B3LN03, D3UEQ0, G2W9F8
      Conserved Domains (1) summary
      pfam03941
      Location:632 → 680
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38283.1

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