Gzmc granzyme C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzmcprovided by MGI
Official Full Name: granzyme Cprovided by MGI
Primary source: MGI:MGI:109256
See related: Ensembl:ENSMUSG00000079186 AllianceGenome:MGI:109256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B10; CCP2; Ctla5; Ctla-5
Summary: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015]
Expression: Biased expression in placenta adult (RPKM 7.5) and subcutaneous fat pad adult (RPKM 0.6) See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56468854..56479102, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (56231397..56241647, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

granzyme C is activated with persistent antigenic stimulation, providing nonredundant backup protection for the host when granzyme B fails.
Title: Differential expression of granzyme B and C in murine cytotoxic lymphocytes.
during late primary alloimmune responses, granzyme C can support CTL-mediated killing by the granule exocytosis pathway in the absence of functional granzymes A or B.
Title: Granzyme C supports efficient CTL-mediated killing late in primary alloimmune responses.
IL-2 increased the expression of perforin and granzyme A, B, and C mRNA; induction of granzyme A, B, and C mRNA required exogenous IL-2, whereas induction of perforin and IFN-gamma expression did not.
Title: IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation.
some cytolytic T lymphocytes mature into perforin/granzyme-expressing effector cells in the mediastinal lymph node and are detectable when they accumulate in lung infection
Title: Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.
the genes for perforin, the three major T cell granzymes (A-C) and IFN-gamma are differentially expressed during primary activation of naive CD8(+) T cells, kinetically and at the single-cell level
Title: The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Gzmc (e-PCR), detects polymorphism
- UniSTS:532234

Gzme (e-PCR), detects polymorphism
- UniSTS:532235

NoName (e-PCR)
- UniSTS:491319

RH131619 (e-PCR)
- UniSTS:214902

AI323531 (e-PCR)
- UniSTS:180638

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in granzyme-mediated programmed cell death signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in granzyme-mediated programmed cell death signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytolytic granule	IEA Inferred from Electronic Annotation more info
located_in cytolytic granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: granzyme C

Names: cytotoxic cell protease 2

NP_001409139.1

EC 3.4.21.-

NP_034501.2

EC 3.4.21.-

XP_011243265.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001422210.1 → NP_001409139.1 granzyme C preproprotein

Status: REVIEWED

Source sequence(s)

AC091783

UniProtKB/Swiss-Prot

P08882, Q61389

UniProtKB/TrEMBL

Q0VB76
NM_010371.4 → NP_034501.2 granzyme C preproprotein

See identical proteins and their annotated locations for NP_034501.2

Status: REVIEWED

Source sequence(s)

AC091783

Consensus CDS

CCDS27146.1

UniProtKB/Swiss-Prot

P08882, Q61389

UniProtKB/TrEMBL

Q0VB76

Related

ENSMUSP00000015585.3, ENSMUST00000015585.4

Conserved Domains (1) summary

cd00190
Location:21 → 244

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

56468854..56479102 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244963.4 → XP_011243265.1 granzyme C isoform X1

See identical proteins and their annotated locations for XP_011243265.1

UniProtKB/Swiss-Prot

P08882, Q61389

UniProtKB/TrEMBL

Q0VB76

Conserved Domains (1) summary

cd00190
Location:21 → 244

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...