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    Scin scinderin [ Mus musculus (house mouse) ]

    Gene ID: 20259, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scinprovided by MGI
    Official Full Name
    scinderinprovided by MGI
    Primary source
    MGI:MGI:1306794
    See related
    Ensembl:ENSMUSG00000002565 AllianceGenome:MGI:1306794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    adseverin
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Located in brush border. Is expressed in several structures, including adrenal gland; female reproductive system; gut; hemolymphoid system gland; and metanephros. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 56.3), large intestine adult (RPKM 22.6) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Scin in Genome Data Viewer
    Location:
    12 B1; 12 18.06 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40109768..40184227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40059769..40134228, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:40763838-40764139 Neighboring gene STARR-positive B cell enhancer ABC_E7130 Neighboring gene ADP-ribosylation factor-like 4A, opposite strand Neighboring gene ADP-ribosylation factor-like 4A Neighboring gene leucine-rich single-pass membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40926695-40926804 Neighboring gene interferon-related developmental regulator 1 Neighboring gene microRNA 1938

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament severing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of megakaryocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sequestering of actin monomers IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sequestering of actin monomers ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    scinderin
    Names
    gelsolin-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146196.1NP_001139668.1  scinderin isoform 1

      See identical proteins and their annotated locations for NP_001139668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC063328, BY201136, Y13971
      Consensus CDS
      CCDS49055.1
      UniProtKB/Swiss-Prot
      O08988, O08990, Q60604, Q6P4N8
      UniProtKB/TrEMBL
      Q69Z71
      Related
      ENSMUSP00000002640.6, ENSMUST00000002640.6
      Conserved Domains (6) summary
      cd11288
      Location:508598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:136225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:10121
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:613711
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:246346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:390486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    2. NM_009132.2NP_033158.2  scinderin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK136080, BY201136, Y13971
      Consensus CDS
      CCDS25891.1
      UniProtKB/TrEMBL
      Q69Z71
      Related
      ENSMUSP00000077573.8, ENSMUST00000078481.14
      Conserved Domains (5) summary
      cd11289
      Location:136225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:10121
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:509611
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:246346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:390486
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      40109768..40184227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)