Slc38a2 solute carrier family 38, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a2provided by MGI
Official Full Name: solute carrier family 38, member 2provided by MGI
Primary source: MGI:MGI:1915010
See related: Ensembl:ENSMUSG00000022462 AllianceGenome:MGI:1915010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATA2; SAT2; SNAT2; mKIAA1382; 5033402L14Rik
Summary: Enables L-glutamine transmembrane transporter activity. Involved in glutamine transport and proline transport. Acts upstream of or within amino acid transport. Located in plasma membrane. Is expressed in several structures, including brain meninges; early embryo; egg cylinder; phalanx; and tooth. Orthologous to human SLC38A2 (solute carrier family 38 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 43.2), limb E14.5 (RPKM 42.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 52.6 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (96585267..96597609, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (96687392..96699728, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NERP-4-SNAT2 axis regulates pancreatic beta-cell maintenance and function.
Title: The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function.
Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis.
Title: Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis.
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.
Title: Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.
Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
Title: Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters.
The neuronal mechanism uncovered here serves to coordinate amino acid and lipid levels and contributes to the development of obesity-related hypertriglyceridemia.
Title: A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.
GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter ATA2.
Title: Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity.
These data reveal an unexpected role for amino acid uptake and the amino acid transporter SNAT2 in regulation of pluripotent cells in culture.
Title: The amino acid transporter SNAT2 mediates L-proline-induced differentiation of ES cells.
The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2+) channels that mediate Ca(2+) influx, thereby leading to an increase in the [Ca(2+)](i) in enteroendocrine cells.
Title: Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2.
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed
Title: Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells.
SNAT2 not only regulates mTOR but also regulates proteolysis through PI3K and provides a link among acidosis, insulin resistance, and protein wasting in skeletal muscle cells.
Title: Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc38a2 (e-PCR), detects polymorphism
- UniSTS:547339

RH136143 (e-PCR)
- UniSTS:210138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acidic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acidic amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables alanine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables alanine:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neutral L-amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neutral L-amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables proline:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-glutamine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-proline import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-serine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-serine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-serine transport	ISO Inferred from Sequence Orthology more info
involved_in acidic amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in alanine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid import	ISO Inferred from Sequence Orthology more info
involved_in amino acid import	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arsenite(3-)	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arsenite(3-)	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glycine betaine transport	IEA Inferred from Electronic Annotation more info
involved_in glycine betaine transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in proline transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate secretion, neurotransmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled neutral amino acid symporter 2

Names: amino acid system A transporter; amino acid transporter A2; sodium-coupled neutral amino acid transporter 2; system A amino acid transporter 2; system A transporter 1; system N amino acid transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355633.1 → NP_001342562.1 sodium-coupled neutral amino acid symporter 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC109201

Conserved Domains (1) summary

cl00456
Location:26 → 412

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_175121.4 → NP_780330.2 sodium-coupled neutral amino acid symporter 2 isoform 1

See identical proteins and their annotated locations for NP_780330.2

Status: VALIDATED

Source sequence(s)

AC109201

Consensus CDS

CCDS27778.1

UniProtKB/Swiss-Prot

Q3TEX3, Q6PFR1, Q6ZPS7, Q810U9, Q8CC66, Q8CD21, Q8CFE6

Related

ENSMUSP00000023099.7, ENSMUST00000023099.8

Conserved Domains (1) summary

cl00456
Location:69 → 491

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

96585267..96597609 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159554.1 → XP_036015447.1 sodium-coupled neutral amino acid symporter 2 isoform X1

UniProtKB/Swiss-Prot

Q3TEX3, Q6PFR1, Q6ZPS7, Q810U9, Q8CC66, Q8CD21, Q8CFE6

Conserved Domains (1) summary

cl00456
Location:69 → 491

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain