Dynlt1b dynein light chain Tctex-type 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dynlt1bprovided by MGI
Official Full Name: dynein light chain Tctex-type 1Bprovided by MGI
Primary source: MGI:MGI:98643
See related: Ensembl:ENSMUSG00000096255 AllianceGenome:MGI:98643
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AGS2; Dynlt1; Tctex1; Tctex-1
Summary: Enables G-protein beta-subunit binding activity and GTP-dependent protein binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of neurogenesis; and regulation of G protein-coupled receptor signaling pathway. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade and positive regulation of neuron projection development. Located in several cellular components, including growth cone; neuronal cell body; and photoreceptor inner segment. Is expressed in several structures, including brain; hemolymphoid system gland; liver; otocyst; and retina. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 809.9), CNS E14 (RPKM 281.5) and 24 other tissues See more
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Genomic context

Location:: 17 A1; 17 3.97 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (6697511..6703695)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (6429530..6440500)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav2.2/N-type calcium channels.
Title: MAP6 interacts with Tctex1 and Ca(v) 2.2/N-type calcium channels to regulate calcium signalling in neurons.
activin receptor IIB as a novel DYNLT1 ligand and suggest that DYNLT1 functions as a molecular dimerization engine bringing together two receptor monomers in the cytoplasmic side of the membrane.
Title: Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.
Dynlt1 modulates orexin signaling by regulating OX1R
Title: Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
Targeted disruption of Tctex-1 by RNA interference significantly impairs bone resorption capacity and mislocalizes Rab3D vesicles in osteoclasts.
Title: Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.
Results identify a regulatory region of the Tctex-1 gene that is capable of directing transgenic expression of green fluorescent protein (GFP) reporter that recapitulates the spatial and temporal expression pattern of endogenous Tctex-1.
Title: Identification of the Tctex-1 regulatory element that directs expression to neural stem/progenitor cells in developing and adult brain.
Thus, Lfc and Tctex-1 interact to regulate cortical neurogenesis, potentially by regulating mitotic spindle orientation.
Title: Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.
Tctex-1 is a novel effector of Gbetagamma, and the Gbetagamma-Tctex-1 complex plays a key role in the dynein-independent function of Tctex-1 in regulating neurite outgrowth in primary hippocampal neurons.
Title: G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.
Association with Tctex-1 and, hence, with the dynein motor complex may offer an explanation for how poliovirus hijacks the cellular transport machinery to retrogradely ascend along the axon to the neuronal cell body.
Title: Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular transport of viral protein in host cell	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein light chain Tctex-type 1

Names: T-complex testis-specific protein 1; activator of G-protein signaling 2; dynein light chain Tctex-type 1D; t-complex testis expressed 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.