Aplp2 amyloid beta precursor-like protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aplp2provided by MGI
Official Full Name: amyloid beta precursor-like protein 2provided by MGI
Primary source: MGI:MGI:88047
See related: Ensembl:ENSMUSG00000031996 AllianceGenome:MGI:88047
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDEBP; APLP-2
Summary: Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including brain development; regulation of epidermal growth factor-activated receptor activity; and suckling behavior. Is active in spine apparatus. Is expressed in several structures, including compacted morula; heart; lower urinary tract; submandibular gland primordium; and ventral grey horn. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 233.8), bladder adult (RPKM 222.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 16.66 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (31060853..31123144, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (31149557..31211848, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
Title: Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
Presenilin and APP Regulate Synaptic Kainate Receptors.
Title: Presenilin and APP Regulate Synaptic Kainate Receptors.
Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization.
Title: Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization.
Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
Title: Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
APPsalpha rescues impaired Ca(2+) homeostasis in APP- and APLP2-deficient hippocampal neurons.
Title: APPsα rescues impaired Ca(2+) homeostasis in APP- and APLP2-deficient hippocampal neurons.
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Title: Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
Title: Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
These data identified APP and APLP2 as modulators of normal myelination and demyelination/remyelination conditions.
Title: Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease.
Title: Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics.
These data support the notion that APP and APLP2 facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery.
Title: APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236086

Aplp1 (e-PCR), detects polymorphism
- UniSTS:259195

AI790698 (e-PCR)
- UniSTS:179870

RH126355 (e-PCR)
- UniSTS:163063

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mating behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within suckling behavior	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in spine apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in spine apparatus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: amyloid beta precursor like protein 2

Names: CDE1-binding protein CDEBP; CDEI box-binding protein; amyloid beta (A4) precursor-like protein 2; amyloid protein homolog; amyloid-like protein 2; sperm membrane protein YWK-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102455.2 → NP_001095925.1 amyloid beta precursor like protein 2 isoform a precursor

See identical proteins and their annotated locations for NP_001095925.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform d.

Source sequence(s)

AK150020, BC052396, BY304295, CT025678

Consensus CDS

CCDS52749.1

UniProtKB/TrEMBL

Q3UDL6, Q60709

Related

ENSMUSP00000072428.8, ENSMUST00000072634.15

Conserved Domains (6) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam00014
Location:309 → 361

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:49 → 147

APP_N; Amyloid A4 N-terminal heparin-binding

pfam10515
Location:697 → 747

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:149 → 204

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:365 → 547

APP_E2; E2 domain of amyloid precursor protein
NM_001102456.2 → NP_001095926.1 amyloid beta precursor like protein 2 isoform b precursor

See identical proteins and their annotated locations for NP_001095926.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform d.

Source sequence(s)

AC114542, BC051999, BY304295

Consensus CDS

CCDS52748.1

UniProtKB/Swiss-Prot

Q06335, Q80US7

UniProtKB/TrEMBL

Q7TT34

Related

ENSMUSP00000078694.8, ENSMUST00000079758.9

Conserved Domains (5) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam02177
Location:49 → 147

APP_N; Amyloid A4 N-terminal heparin-binding

pfam10515
Location:653 → 703

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:149 → 204

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:309 → 491

APP_E2; E2 domain of amyloid precursor protein
NM_001357698.1 → NP_001344627.1 amyloid beta precursor like protein 2 isoform d precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).

Source sequence(s)

AC114542, CT025678

UniProtKB/TrEMBL

Q3UDL6, Q61482

Related

ENSMUSP00000149732.2, ENSMUST00000213254.2

Conserved Domains (4) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam00014
Location:309 → 361

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam10515
Location:709 → 759

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12925
Location:365 → 547

APP_E2; E2 domain of amyloid precursor protein
NM_009691.3 → NP_033821.1 amyloid beta precursor like protein 2 isoform c precursor

See identical proteins and their annotated locations for NP_033821.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform d.

Source sequence(s)

AC114542, BC052396, BY304295

Consensus CDS

CCDS90528.1

UniProtKB/TrEMBL

Q64348, Q7TT34

Related

ENSMUSP00000149023.2, ENSMUST00000217641.2

Conserved Domains (5) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam02177
Location:49 → 147

APP_N; Amyloid A4 N-terminal heparin-binding

pfam10515
Location:641 → 691

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:149 → 204

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:309 → 491

APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

31060853..31123144 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509952.1 → XP_006510015.1 amyloid beta precursor like protein 2 isoform X1

UniProtKB/TrEMBL

Q3UDL6

Conserved Domains (4) summary

smart00006
Location:1 → 151

A4_EXTRA; amyloid A4

pfam00014
Location:256 → 307

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam10515
Location:656 → 706

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12925
Location:312 → 494

APP_E2; E2 domain of amyloid precursor protein