Alb albumin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Albprovided by MGI
Official Full Name: albuminprovided by MGI
Primary source: MGI:MGI:87991
See related: Ensembl:ENSMUSG00000029368 AllianceGenome:MGI:87991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Alb1; Alb-1; BCL002
Summary: This gene encodes albumin, an abundant plasma protein essential for maintaining oncotic pressure that functions as a carrier protein for various molecules such as steriods and fatty acids in blood. This gene is primarily expressed in liver where the encoded protein undergoes proteolytic processing before secretion into the plasma. [provided by RefSeq, Oct 2015]
Expression: Biased expression in liver adult (RPKM 14891.4), liver E14.5 (RPKM 6823.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 44.7 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (90608729..90624461)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (90460870..90476602)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
Title: WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
Study shows that P573 of mouse serum albumin (MSA) is crucial for strong neonatal Fc receptor binding and that the single amino acid difference between human serum albumin (K573) and MSA at this position contributes greatly to distinct cross species binding which should be taken into consideration in design of albumin-based drugs and evaluation in mouse models.
Title: Human and mouse albumin bind their respective neonatal Fc receptors differently.
Knockout of FcRn leads to IgG accumulation in podocytes but does not alter albumin trafficking.
Title: Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo.
findings suggest that HMGB1 induces the transcytosis of albumin via RAGE-dependent Src phosphorylation and Cav-1 phosphorylation. These studies revealed a new mechanism of HMGB1-induced endothelial hyperpermeability.
Title: High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway.
Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase of kidney injury and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. These markers could detect higher risk of progression to CKD.
Title: Increase in urinary markers during the acute phase reflects the degree of chronic tubulointerstitial injury after ischemia-reperfusion renal injury.
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
Title: Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
We provide evidence of a transcytosis within the kidney tubular system that protects albumin and IgG from lysosomal degradation, allowing these proteins to be recycled intact.
Title: Albumin is recycled from the primary urine by tubular transcytosis.
albumin may play a distinct role in adipocyte differentiation by promoting lipid accumulation.
Title: Albumin expression is required for adipocyte differentiation of 3T3-L1 cells.
No binding of albumin was observed at physiological pH to neonatal Fc receptor. At acidic pH, a 100-fold difference in binding affinity was observed.
Title: Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.
albumin enhancer/promoter was succesfully used for trasient transfection of fluorescent gene reporters (for cell sorting) in ES spontaneously differentiated into hepatocytes.
Title: Transient gene delivery for functional enrichment of differentiating embryonic stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (15) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Alb1 (e-PCR), detects polymorphism
- UniSTS:141069

PMC130551P1 (e-PCR)
- UniSTS:270615

D14Wox11 (e-PCR)
- UniSTS:118050

Alb (e-PCR), detects polymorphism
- UniSTS:516665

PMC151813P1 (e-PCR)
- UniSTS:271181

Alb (e-PCR), detects polymorphism
- UniSTS:527210

PMC86057P4 (e-PCR)
- UniSTS:273516

Alb (e-PCR), detects polymorphism
- UniSTS:516524

UniSTS:465369 (e-PCR)
- UniSTS:465369

Alb (e-PCR), detects polymorphism
- UniSTS:465369

PMC275467P2 (e-PCR)
- UniSTS:272383

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enterobactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables enterobactin binding	ISO Inferred from Sequence Orthology more info
enables enterobactin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables exogenous protein binding	IEA Inferred from Electronic Annotation more info
enables exogenous protein binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IEA Inferred from Electronic Annotation more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables modified amino acid binding	ISO Inferred from Sequence Orthology more info
contributes_to oxygen binding	ISO Inferred from Sequence Orthology more info
contributes_to oxygen binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: albumin

Names: albumin 1; serum albumin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.