U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ctsf cathepsin F [ Mus musculus (house mouse) ]

    Gene ID: 56464, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctsfprovided by MGI
    Official Full Name
    cathepsin Fprovided by MGI
    Primary source
    MGI:MGI:1861434
    See related
    Ensembl:ENSMUSG00000083282 AllianceGenome:MGI:1861434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in adrenal gland and blood vessel. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 122.0), ovary adult (RPKM 42.6) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ctsf in Genome Data Viewer
    Location:
    19 A; 19 4.12 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4905153..4910946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4855165..4860918)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase Neighboring gene STARR-positive B cell enhancer ABC_E9452 Neighboring gene coiled-coil domain containing 87 Neighboring gene STARR-seq mESC enhancer starr_45366 Neighboring gene actinin alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E3236 Neighboring gene zinc finger, DHHC domain containing 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type peptidase activity PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis  
    involved_in proteolysis involved in protein catabolic process  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    is_active_in lysosome  
    located_in lysosome  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    cathepsin F
    NP_063914.1
    XP_030106864.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019861.2NP_063914.1  cathepsin F precursor

      See identical proteins and their annotated locations for NP_063914.1

      Status: VALIDATED

      Source sequence(s)
      AC141437
      Consensus CDS
      CCDS29440.1
      UniProtKB/Swiss-Prot
      Q9R013, Q9WUT4
      UniProtKB/TrEMBL
      Q9ES93
      Related
      ENSMUSP00000112481.2, ENSMUST00000119694.3
      Conserved Domains (2) summary
      smart00848
      Location:165221
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:249460
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4905153..4910946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251004.2XP_030106864.1  cathepsin F isoform X1

      UniProtKB/TrEMBL
      Q99KQ9
      Conserved Domains (2) summary
      smart00848
      Location:561
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:89299
      Peptidase_C1; Papain family cysteine protease
    External link. Please review our privacy policy.