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    Caprin1 cell cycle associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 53872, updated on 9-Dec-2024

    Summary

    Official Symbol
    Caprin1provided by MGI
    Official Full Name
    cell cycle associated protein 1provided by MGI
    Primary source
    MGI:MGI:1858234
    See related
    Ensembl:ENSMUSG00000027184 AllianceGenome:MGI:1858234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P137; Gpiap; Gpiap1; rng105; Caprin-1; Mmgpip137
    Summary
    Predicted to enable several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in positive regulation of dendritic spine morphogenesis. Acts upstream of or within generation of neurons; intracellular mRNA localization; and synapse assembly. Located in cytoplasmic stress granule. Is active in dendrite and synapse. Is expressed in central nervous system; eye; and genitourinary system. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.6), whole brain E14.5 (RPKM 41.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Caprin1 in Genome Data Viewer
    Location:
    2 E2; 2 54.43 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103593292..103627946, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103762945..103797669, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103502331-103502560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103522571-103522790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103543647-103543756 Neighboring gene STARR-positive B cell enhancer ABC_E11149 Neighboring gene N-acetyltransferase 10 Neighboring gene STARR-positive B cell enhancer ABC_E4483 Neighboring gene STARR-positive B cell enhancer mm9_chr2:103625945-103626245 Neighboring gene STARR-seq mESC enhancer starr_05272 Neighboring gene STARR-seq mESC enhancer starr_05273 Neighboring gene RIKEN cDNA 4930547E08 gene Neighboring gene predicted gene 13880

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular function activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membraneless organelle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membraneless organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membraneless organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caprin-1
    Names
    GPI-anchored membrane protein 1
    GPI-anchored protein p137
    GPI-p137
    RNA granule protein 105
    cytoplasmic activation- and proliferation-associated protein 1
    cytoplasmic activation/proliferation-associated protein 1
    membrane component chromosome 11 surface marker 1
    p137GPI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111289.2NP_001104759.1  caprin-1 isoform a

      See identical proteins and their annotated locations for NP_001104759.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BX537331
      Consensus CDS
      CCDS16481.1
      UniProtKB/Swiss-Prot
      Q60758, Q60865, Q61620, Q6IMN3, Q7TT26
      Related
      ENSMUSP00000106777.2, ENSMUST00000111147.8
      Conserved Domains (1) summary
      pfam12287
      Location:365677
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    2. NM_001111290.2NP_001104760.1  caprin-1 isoform b

      See identical proteins and their annotated locations for NP_001104760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      BX537331
      UniProtKB/Swiss-Prot
      Q60865
      Conserved Domains (2) summary
      pfam12287
      Location:357670
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:130245
      Caprin-1_dimer; Caprin-1 dimerization domain
    3. NM_001111291.2NP_001104761.1  caprin-1 isoform c

      See identical proteins and their annotated locations for NP_001104761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      BX537331
      UniProtKB/Swiss-Prot
      Q60865
      Conserved Domains (2) summary
      pfam12287
      Location:357683
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:130245
      Caprin-1_dimer; Caprin-1 dimerization domain
    4. NM_001111292.2NP_001104762.1  caprin-1 isoform c

      See identical proteins and their annotated locations for NP_001104762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      BX537331
      UniProtKB/Swiss-Prot
      Q60865
      Conserved Domains (2) summary
      pfam12287
      Location:357683
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:130245
      Caprin-1_dimer; Caprin-1 dimerization domain
    5. NM_001412568.1NP_001399497.1  caprin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      BX537331
    6. NM_001412569.1NP_001399498.1  caprin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      BX537331
    7. NM_001412570.1NP_001399499.1  caprin-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      BX537331
    8. NM_001412571.1NP_001399500.1  caprin-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      BX537331
    9. NM_001412572.1NP_001399501.1  caprin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      BX537331
    10. NM_001412574.1NP_001399503.1  caprin-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      BX537331
    11. NM_001412575.1NP_001399504.1  caprin-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      BX537331
    12. NM_001412576.1NP_001399505.1  caprin-1 isoform h

      Status: VALIDATED

      Source sequence(s)
      BX537331
    13. NM_001412577.1NP_001399506.1  caprin-1 isoform i

      Status: VALIDATED

      Source sequence(s)
      BX537331
    14. NM_001412578.1NP_001399507.1  caprin-1 isoform i

      Status: VALIDATED

      Source sequence(s)
      BX537331
    15. NM_016739.4NP_058019.2  caprin-1 isoform a

      See identical proteins and their annotated locations for NP_058019.2

      Status: VALIDATED

      Source sequence(s)
      BX537331
      Consensus CDS
      CCDS16481.1
      UniProtKB/Swiss-Prot
      Q60758, Q60865, Q61620, Q6IMN3, Q7TT26
      Related
      ENSMUSP00000028607.7, ENSMUST00000028607.13
      Conserved Domains (1) summary
      pfam12287
      Location:365677
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103593292..103627946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)