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    PYY2 peptide YY 2 (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 23615, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PYY2provided by HGNC
    Official Full Name
    peptide YY 2 (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:9749
    See related
    Ensembl:ENSG00000290671 MIM:606637; AllianceGenome:HGNC:9749
    Gene type
    pseudo
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal (RPKM 3.8), testis (RPKM 1.2) and 3 other tissues See more
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    Genomic context

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    See PYY2 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28226563..28228060)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29168391..29169888)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26553589..26555086)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nemo like kinase Neighboring gene ribosomal protein S29 pseudogene 22 Neighboring gene uncharacterized LOC105371711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11919 Neighboring gene uncharacterized LOC105371710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26553198-26553848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26554499-26555148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26555149-26555798 Neighboring gene Sharpr-MPRA regulatory region 13006 Neighboring gene uncharacterized LOC105371712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8334 Neighboring gene leucine-rich repeat-containing protein 37A3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:26591629-26592828 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:26594224-26595423 Neighboring gene pancreatic polypeptide 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The origin and evolution of peptide YY (PYY) and pancreatic polypeptide (PP). Conlon JM. Peptides, 2002 Feb. PMID 11825642
    2. Peptide YY-2 (PYY2) and pancreatic polypeptide-2 (PPY2): species-specific evolution of novel members of the neuropeptide Y gene family. Couzens M, et al. Genomics, 2000 Mar 15. PMID 10756099
    3. Seminalplasmin: recent evolution of another member of the neuropeptide Y gene family. Herzog H, et al. Proc Natl Acad Sci U S A, 1995 Jan 17. PMID 7831336, Free PMC Article
    4. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Ma L, et al. Diabetes, 2005 May. PMID 15855352, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • peptide YY, 2 (seminalplasmin)
    • seminalplasmin

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003064.2 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AC061975
      Related
      ENST00000441253.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28226563..28228060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      29168391..29169888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021093.1: Suppressed sequence

      Description
      NM_021093.1: This RefSeq was permanently suppressed because we now believe this locus is a pseudogene rather than a protein-coding gene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRI6.1 GenPept UniProtKB/Swiss-Prot:Q9NRI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.