KLF16 KLF transcription factor 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF16provided by HGNC
Official Full Name: KLF transcription factor 16provided by HGNC
Primary source: HGNC:HGNC:16857
See related: Ensembl:ENSG00000129911 MIM:606139; AllianceGenome:HGNC:16857
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DRRF; BTEB4; NSLP2
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within G protein-coupled dopamine receptor signaling pathway. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 6.7), colon (RPKM 5.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (1852399..1876536, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (1823714..1847856, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (1852398..1863578, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm.
Title: SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm.
circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through Sponging miR-29a-3p and miR-122-5p.
Title: circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through Sponging miR-29a-3p and miR-122-5p.
KLF16 enhances stress tolerance of colorectal carcinomas by modulating nucleolar homeostasis and translational reprogramming.
Title: KLF16 enhances stress tolerance of colorectal carcinomas by modulating nucleolar homeostasis and translational reprogramming.
Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer.
Title: Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer.
circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.
Title: circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.
Silencing KLF16 inhibits oral squamous cell carcinoma cell proliferation by arresting the cell cycle and inducing apoptosis.
Title: Silencing KLF16 inhibits oral squamous cell carcinoma cell proliferation by arresting the cell cycle and inducing apoptosis.
PRKD3 promotes malignant progression of OSCC by downregulating KLF16 expression.
Title: PRKD3 promotes malignant progression of OSCC by downregulating KLF16 expression.
Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS.
Title: Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS.
KLF16 overexpression deleteriously affects the proliferation and migration of retinoblastoma by transcriptionally repressing BCL2L15.
Title: KLF16 overexpression deleteriously affects the proliferation and migration of retinoblastoma by transcriptionally repressing BCL2L15.
KLF16 is a key regulator of glioma cell proliferation by directly targeting TFAM
Title: KLF16 suppresses human glioma cell proliferation and tumourigenicity by targeting TFAM.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480963

RH102139 (e-PCR)
- UniSTS:96473

NoName (e-PCR)
- UniSTS:484060

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 16

Names: BTE-binding protein 4; Kruppel like factor 16; basic transcription element binding protein 4; dopamine receptor regulating factor; novel Sp1-like zinc finger transcription factor 2; transcription factor BTEB4; transcription factor NSLP2; unknown transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031918.4 → NP_114124.1 Krueppel-like factor 16

See identical proteins and their annotated locations for NP_114124.1

Status: VALIDATED

Source sequence(s)

AC012615, AF327440, BE243730, BQ447922

Consensus CDS

CCDS12075.1

UniProtKB/Swiss-Prot

Q9BXK1

Related

ENSP00000250916.3, ENST00000250916.6

Conserved Domains (4) summary

COG5048
Location:125 → 189

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:132 → 151

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:187 → 209

zf-C2H2; Zinc finger, C2H2 type

cd21573
Location:2 → 88

KLF16_N; N-terminal domain of Kruppel-like factor 16