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    Cplx2 complexin 2 [ Mus musculus (house mouse) ]

    Gene ID: 12890, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cplx2provided by MGI
    Official Full Name
    complexin 2provided by MGI
    Primary source
    MGI:MGI:104726
    See related
    Ensembl:ENSMUSG00000025867 Ensembl:ENSMUSG00000112941 AllianceGenome:MGI:104726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    921-L; Gm34843
    Summary
    Predicted to enable calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in positive regulation of synaptic plasticity and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Is active in calyx of Held and glutamatergic synapse. Is expressed in nervous system; retina layer; and skeletal muscle. Used to study schizophrenia. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 102.7), frontal lobe adult (RPKM 85.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Cplx2 in Genome Data Viewer
    Location:
    13 B1; 13 28.59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54455447..54531736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54301964..54383923)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene histamine receptor H2 Neighboring gene predicted gene 16578 Neighboring gene predicted gene, 40955 Neighboring gene predicted gene, 48622 Neighboring gene STARR-positive B cell enhancer ABC_E5398 Neighboring gene STARR-positive B cell enhancer ABC_E11782 Neighboring gene STARR-positive B cell enhancer ABC_E7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54548428-54548615 Neighboring gene STARR-positive B cell enhancer ABC_E10794 Neighboring gene THO complex 3 Neighboring gene predicted gene, 53205 Neighboring gene predicted gene 2830

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    complexin-2
    Names
    CPX II
    complexin II
    synaphin-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362218.1NP_001349147.1  complexin-2

      Status: VALIDATED

      Source sequence(s)
      AC242674, AW492120, CJ108367, CX240169
      Consensus CDS
      CCDS36667.1
      UniProtKB/Swiss-Prot
      P84086, Q32KK4
      Conserved Domains (1) summary
      pfam05835
      Location:1133
      Synaphin; Synaphin protein
    2. NM_009946.3NP_034076.1  complexin-2

      See identical proteins and their annotated locations for NP_034076.1

      Status: VALIDATED

      Source sequence(s)
      AC242674, BN000502
      Consensus CDS
      CCDS36667.1
      UniProtKB/Swiss-Prot
      P84086, Q32KK4
      Related
      ENSMUSP00000026985.9, ENSMUST00000026985.9
      Conserved Domains (1) summary
      pfam05835
      Location:1133
      Synaphin; Synaphin protein

    RNA

    1. NR_155492.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BE984504, BM941693, CJ108367, CX240169
      Related
      ENSMUST00000240905.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54455447..54531736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315376.3XP_017170865.1  complexin-2 isoform X1

      UniProtKB/Swiss-Prot
      P84086, Q32KK4
      Conserved Domains (1) summary
      pfam05835
      Location:1133
      Synaphin; Synaphin protein