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    Osgep O-sialoglycoprotein endopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 66246, updated on 9-Dec-2024

    Summary

    Official Symbol
    Osgepprovided by MGI
    Official Full Name
    O-sialoglycoprotein endopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1913496
    See related
    Ensembl:ENSMUSG00000006289 AllianceGenome:MGI:1913496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCPL-1; PRSMG1; 1500019L24Rik
    Summary
    Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 44.1), adrenal adult (RPKM 34.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Osgep in Genome Data Viewer
    Location:
    14 C1; 14 26.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51152831..51162350, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50915374..50924893, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene telomerase associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8557 Neighboring gene predicted gene, 26782 Neighboring gene kelch-like 33 Neighboring gene Apex1 promoter region Neighboring gene STARR-seq mESC enhancer starr_36659 Neighboring gene apurinic/apyrimidinic endonuclease 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables N(6)-L-threonylcarbamoyladenine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of EKC/KEOPS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tRNA N6-adenosine threonylcarbamoyltransferase
    Names
    N6-L-threonylcarbamoyladenine synthase
    mOsgep
    probable O-sialoglycoprotein endopeptidase
    probable tRNA N6-adenosine threonylcarbamoyltransferase
    probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
    t(6)A synthase
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep
    tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
    NP_598437.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133676.2NP_598437.2  tRNA N6-adenosine threonylcarbamoyltransferase

      See identical proteins and their annotated locations for NP_598437.2

      Status: VALIDATED

      Source sequence(s)
      AK142730, CA481753
      Consensus CDS
      CCDS27026.1
      UniProtKB/TrEMBL
      A0A0R4J1Y3, Q3UQ67
      Related
      ENSMUSP00000124039.2, ENSMUST00000159292.8
      Conserved Domains (2) summary
      PTZ00340
      Location:4335
      PTZ00340; O-sialoglycoprotein endopeptidase-like protein; Provisional
      cl22532
      Location:4108
      Carbam_trans_N; Carbamoyltransferase N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51152831..51162350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)